Clusters of DCX+ cells 'trapped' in the subcortical white matter of early postnatal Cetartiodactyla (Tursiops truncatus, Stenella coeruloalba and Ovis aries)

Autor: Ottavia Palazzo, Roberta Parolisi, Frédéric Lévy, Maryse Meurisse, Luca Bonfanti, Chiara La Rosa
Přispěvatelé: Neuroscience Institute Cavalieri-Ottolenghi, Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), ANR programme blanc, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Doublecortin Domain Proteins
Male
Doublecortin Protein
Histology
Brain development
Comparative neuroscience
Doublecortin
Immature neurons
Mammals
Structural plasticity
Anatomy
Neuroscience (all)
immature neurons
Neurogenesis
[SDV]Life Sciences [q-bio]
Subventricular zone
brain development
White matter
03 medical and health sciences
Monophyly
0302 clinical medicine
Species Specificity
Stenella
Cell Movement
doublecortin
biology.animal
Cortex (anatomy)
medicine
Animals
mammals
[INFO]Computer Science [cs]
Sheep
Domestic
Cell Proliferation
biology
General Neuroscience
Neuropeptides
Brain
Embryonic stem cell
White Matter
structural plasticity
Bottle-Nosed Dolphin
Anatomy
Comparative
030104 developmental biology
medicine.anatomical_structure
Evolutionary biology
biology.protein
Female
comparative neuroscience
Microtubule-Associated Proteins
030217 neurology & neurosurgery
Zdroj: Brain Structure and Function
Brain Structure and Function, Springer Verlag, 2018, pp.1-20. ⟨10.1007/s00429-018-1708-z⟩
ISSN: 1863-2653
1863-2661
DOI: 10.1007/s00429-018-1708-z⟩
Popis: International audience; The cytoskeletal protein doublecortin (DCX) is a marker for neuronal cells retaining high potential for structural plasticity, originating from both embryonic and adult neurogenic processes. Some of these cells have been described in the subcortical white matter of neonatal and postnatal mammals. In mice and humans it has been shown they are young neurons migrating through the white matter after birth, reaching the cortex in a sort of protracted neurogenesis. Here we show that DCX+ cells in the white matter of neonatal and young Cetartiodactyla (dolphin and sheep) form large clusters which are not newly generated (in sheep, and likely neither in dolphins) and do not reach the cortical layers, rather appearing “trapped” in the white matter tissue. No direct contact or continuity can be observed between the subventricular zone region and the DCX+ clusters, thus indicating their independence from any neurogenic source (in dolphins further confirmed by the recent demonstration that periventricular neurogenesis is inactive since birth). Cetartiodactyla include two orders of large-brained, relatively long-living mammals (cetaceans and artiodactyls) which were recognized as two separate monophyletic clades until recently, yet, despite the evident morphological distinctions, they are monophyletic in origin. The brain of Cetartiodactyla is characterized by an advanced stage of development at birth, a feature that might explain the occurrence of “static” cell clusters confined within their white matter. These results further confirm the existence of high heterogeneity in the occurrence, distribution and types of structural plasticity among mammals, supporting the emerging view that multiple populations of DCX+, non-newly generated cells can be abundant in large-brained, long-living species.
Databáze: OpenAIRE
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