Gastrointestinal chronopharmacology: Physiology, pharmacology and therapeutic implications
| Autor: | S.W. Sanders, J.G. Moore |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Drug Periodicity Chronobiology Gastric emptying Gastrointestinal Diseases media_common.quotation_subject Physiology Biology Mechanism of action Digestive System Physiological Phenomena Oral administration medicine Animals Humans Gastric acid Pharmacology (medical) Circadian rhythm medicine.symptom Digestive System media_common Ultradian rhythm |
| Zdroj: | Pharmacology & Therapeutics. 54:1-15 |
| ISSN: | 0163-7258 |
| Popis: | This chapter discusses the influence of ultradian and circadian rhythms of gastrointestinal motor and secretory function on the action of orally administered drugs. Most drugs exhibit more rapid absorption in the morning compared to the evening due, in part, the circadian alterations in gastric emptying. Gastric acid secretion and gastrointestinal toxicity to oral drugs also display circadian rhythmicity. These observations provide a rationale for use or avoidance of drugs based on time-of-day dosing considerations. The chronopharmacological behavior of a drug may thus play an important role in the effectiveness of any oral medication treatment schedule. |
| Databáze: | OpenAIRE |
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