Using the lymph nodal ratio to predict the risk of locoregional recurrence in lymph node-positive breast cancer patients treated with mastectomy without radiation therapy
| Autor: | Feng-Yan Li, Jia-Yuan Sun, Huan-Xin Lin, Qin Lin, Zhen-Yu He, San-Gang Wu, Yong Chen |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Oncology medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Kaplan-Meier Estimate Disease-Free Survival Lymph node ratio Young Adult Breast cancer Internal medicine medicine Humans Recurrences Radiology Nuclear Medicine and imaging Stage (cooking) Lymph node Mastectomy Aged Neoplasm Staging Retrospective Studies Aged 80 and over Univariate analysis Radiotherapy business.industry Research Middle Aged Prognosis medicine.disease Radiation therapy Axilla medicine.anatomical_structure Radiology Nuclear Medicine and imaging Lymphatic Metastasis Lymph Node Excision Female Lymph Nodes Lymph Neoplasm Recurrence Local business |
| Zdroj: | Radiation Oncology (London, England) |
| ISSN: | 1748-717X |
| DOI: | 10.1186/1748-717x-8-119 |
| Popis: | Background To evaluate the prognostic value of axillary lymph node ratio (LNR) as compared to the number of involved nodes (pN stage) in patients with axillary lymph node-positive breast cancer treated with mastectomy without radiation. Methods We performed a retrospective analysis of the clinical data of patients with stage II-III node-positive breast cancer (N=1068) between 1998 and 2007. Locoregional recurrence-free survival (LRFS) and overall survival (OS) were compared based on the LNR and pN staging. Results A total of 780 cases were classified as pN1, 183 as pN2, and 105 as pN3. With respect to LNR, 690 cases had a LNR from 0.01-0.20, 269 cases a LNR from 0.21-0.65, and 109 cases a LNR > 0.65. The median follow-up time was 62 months. Univariate analysis showed that both LNR and pN stage were prognostic factors of LRFS and OS (p0.05). In subgroup analysis, the LNR identified groups of patients with different survival rates based on pN stage. Conclusions LNR is superior to pN staging as a prognostic factor in lymph node-positive breast cancer after mastectomy, and should be used as one of the indications for adjuvant radiation therapy. |
| Databáze: | OpenAIRE |
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