Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis
| Autor: | Gang Xu, Dong Li, Tong Liu, Michael Shehata, Panagiotis Korantzopoulos, Xunzhang Wang, Guangping Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Peptidyl-Dipeptidase A Bioinformatics Peptidyl-Dipeptidase A/*genetics Renin-Angiotensin System INDEL Mutation Risk Factors Physiology (medical) Internal medicine Atrial Fibrillation Medicine Insertion deletion Humans Polymorphism Genetic/genetics Aged Polymorphism Genetic biology business.industry Case-control study Angiotensin-converting enzyme Atrial fibrillation Atrial Fibrillation/epidemiology/*genetics/physiopathology Middle Aged medicine.disease Clinical trial INDEL Mutation/*genetics Endocrinology Meta-analysis Case-Control Studies biology.protein Dominant model Female Gene polymorphism Renin-Angiotensin System/physiology Cardiology and Cardiovascular Medicine business |
| Popis: | AIMS: Recent observations have raised concerns regarding the activation of the renin-angiotensin system and the development of atrial fibrillation (AF). Some initial studies indicated an association between an angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism and AF, however, the results have been inconsistent. Our aim was to perform a meta-analysis of relevant studies to assess the validity of this association. METHODS AND RESULTS: PubMed, Cochrane clinical trials database, and EMBASE were searched through July 2009, and a manual search was also performed. Of the 68 initially identified studies, 18 case-control studies with 7577 patients were finally analysed. No statistically significant associations were found between the ACE I/D polymorphism and AF risk in the genetic additive model and dominant model, whereas a significant association was observed in the recessive model. A significant heterogeneity between individual studies was evident in all three models. Subgroup analyses showed a strong association between the ACE I/D polymorphism and hypertensive AF without significant heterogeneity. CONCLUSION: Our meta-analysis suggests that there is insufficient evidence to demonstrate an association between ACE I/D polymorphism and AF risk. However, there seems to be a significant association between ACE I/D gene polymorphic variation and AF in patients with hypertension. Additional studies are warranted to further explore this association in ethnically diverse populations and varied cardiovascular substrates. Europace |
| Databáze: | OpenAIRE |
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