Overactive Bladder and Storage Lower Urinary Tract Symptoms Following Radical Prostatectomy
| Autor: | Karthik K. Tennankore, Jeffrey G Himmelman, Jerzy B. Gajewski, Gregory W. Hosier, Ashley Cox |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology urologic and male genital diseases Cohort Studies 03 medical and health sciences Prostate cancer 0302 clinical medicine Postoperative Complications Lower Urinary Tract Symptoms Lower urinary tract symptoms medicine Nocturia Humans Aged Retrospective Studies Prostatectomy Urinary bladder Radiotherapy business.industry Urinary Bladder Overactive Prostatic Neoplasms Retrospective cohort study Middle Aged medicine.disease humanities female genital diseases and pregnancy complications Radiation therapy medicine.anatomical_structure Overactive bladder 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | Urology. 94 |
| ISSN: | 1527-9995 |
| Popis: | To describe the rate of overactive bladder (OAB) and storage lower urinary tract symptoms following radical prostatectomy (RP) and determine if subsequent radiation increases the risk of OAB.We reviewed all patients who underwent open RP at our tertiary care institution from January 2006 to June 2011. Primary outcomes were the proportion of patients with new OAB and time to development of OAB in those treated with RP alone vs RP plus radiation. Secondary outcomes included the proportion of patients treated for OAB. A Cox survival analysis was used to assess the impact of radiation on development of OAB.Of the 875 patients who met study criteria, 19% of patients developed de novo OAB defined as urgency with or without frequency and nocturia. A total of 256 patients (29%) developed 1 or more urinary symptoms including nocturia (22%), frequency (21%), urgency (19%), and urge incontinence (6%) following RP. After adjusting for age, body mass index, smoking status, cancer stage, and nerve-sparing status, radiation therapy was associated with an increased relative hazard of OAB (5.59; 95% CI 3.63-8.61, P .001). Among men classified with de novo OAB, only 41% received treatment.OAB and storage lower urinary tract symptoms are prevalent in men post-RP. Adjuvant or salvage radiation therapy increases the risk of developing OAB after RP. OAB may be undertreated in men following prostate cancer treatment. |
| Databáze: | OpenAIRE |
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