Latent CMV Infection Is Associated With Lower Influenza Virus-Specific Memory T-Cell Frequencies, but Not With an Impaired T-Cell Response to Acute Influenza Virus Infection
Autor: | Sara P. H. van den Berg, Josien Lanfermeijer, Ronald H. J. Jacobi, Marion Hendriks, Martijn Vos, Roos van Schuijlenburg, Nening M. Nanlohy, José A. M. Borghans, Josine van Beek, Debbie van Baarle, Jelle de Wit |
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Rok vydání: | 2021 |
Předmět: |
Male
0301 basic medicine T-Lymphocytes medicine.medical_treatment Cytomegalovirus T-Cell Antigen Receptor Specificity influenza infection medicine.disease_cause Severity of Illness Index immune response 0302 clinical medicine Immunology and Allergy Cellular Senescence Original Research Aged 80 and over Coinfection virus diseases Middle Aged Virus Latency medicine.anatomical_structure Cytokine Influenza A virus Cytomegalovirus Infections Cytokines Female Adult T cell Immunology Virus Young Adult 03 medical and health sciences Immune system Influenza Human medicine Humans cytomegalovirus infection Aged business.industry RC581-607 030104 developmental biology ageing Immunologic diseases. Allergy Serostatus business Immunologic Memory Memory T cell CD8 030215 immunology |
Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
ISSN: | 1664-3224 |
Popis: | Latent infection with cytomegalovirus (CMV) is assumed to contribute to the age-associated decline of the immune system. CMV induces large changes in the T-cell pool and may thereby affect other immune responses. CMV is expected to impact especially older adults, who are already at higher risk of severe disease and hospitalization upon infections such as influenza virus (IAV) infection. Here, we investigated the impact of CMV infection on IAV-specific CD8+ T-cell frequencies in healthy individuals (n=96) and the response to IAV infection in older adults (n=72). IAV-specific memory T-cell frequencies were lower in healthy CMV+ older individuals compared to healthy CMV- older individuals. Upon acute IAV infection, CMV serostatus or CMV-specific antibody levels were not negatively associated with IAV-specific T-cell frequencies, function, phenotype or T-cell receptor repertoire diversity. This suggests that specific T-cell responses upon acute IAV infection are not negatively affected by CMV. In addition, we found neither an association between CMV infection and inflammatory cytokine levels in serum during acute IAV infection nor between cytokine levels and the height of the IAV-specific T-cell response upon infection. Finally, CMV infection was not associated with increased severity of influenza-related symptoms. In fact, CMV infection was even associated with increased IAV-specific T-cell responses early upon acute IAV infection. In conclusion, although associated with lower frequencies of memory IAV-specific T cells in healthy individuals, CMV infection does not seem to hamper the induction of a proper T-cell response during acute IAV infection in older adults. |
Databáze: | OpenAIRE |
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