The effect of carmustine on Bergmann cells of the cerebellum
| Autor: | Hugo Sánchez-Castillo, Armando Becerra-Hernández, María Alejandra González-González, Aline Ostos-Valverde, Ataúlfo Martínez-Torres |
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| Rok vydání: | 2015 |
| Předmět: |
Genetically modified mouse
Alkylating Agents Cerebellum Offspring Cell Mice Transgenic Motor Activity Biology Fourth ventricle Pregnancy medicine Animals Carmustine General Neuroscience Cortical dysplasia medicine.disease Malformations of Cortical Development medicine.anatomical_structure nervous system Maternal Exposure Female Soma Neuroscience medicine.drug |
| Zdroj: | Neuroscience Letters. 595:18-24 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2015.03.068 |
| Popis: | Administration of the alkylating agent carmustine to pregnant mice induces hyperlocomotion in the offspring. Motor performance was evaluated by the rotarod task, which revealed that these animals have diminished Grab Frequency and a higher Performance Index, whereas Error of Latency and Latency to Fall were unaffected. Considering the recently revealed role of Bergmann cells of cerebellum in the control of motor activity, we used the transgenic mice GFAP-GFP to explore the impact of carmustine on the organization of these glial cells. Multiple examples of cell layer disorganization were detected; many soma of Bergmann cells were displaced to the external cell layer, and their processes were not well defined until young adulthood. In addition, the roof of the fourth ventricle was convoluted. These observations suggest that the exacerbated locomotion induced by carmustine may be due, in part, to the altered organization of the cell layers of cerebellum. |
| Databáze: | OpenAIRE |
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