Comparison of Circulating Adiponectin and Proinflammatory Markers Regarding Their Association With Metabolic Syndrome in Japanese Men
| Autor: | Toyoaki Murohara, Rei Otsuka, Koji Tamakoshi, Kunihiro Matsushita, Kaichiro Sugiura, Hiroshi Yatsuya, Takahisa Kondo, Seiko Takefuji, Keiko Wada, Hideaki Toyoshima |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Disease Proinflammatory cytokine Insulin resistance Asian People Internal medicine medicine Humans Medical history Risk factor National Cholesterol Education Program Inflammation Metabolic Syndrome Adiponectin Interleukin-6 Tumor Necrosis Factor-alpha business.industry Smoking Age Factors Middle Aged medicine.disease C-Reactive Protein Endocrinology Regression Analysis Insulin Resistance Metabolic syndrome Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 26:871-876 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.0000208363.85388.8f |
| Popis: | Background— Anti-inflammatory and proinflammatory molecules purportedly play an important role in developing metabolic syndrome (MetS). However, little is known as to the relative importance of these molecules in the association with MetS. Methods and Results— We studied 624 middle-aged Japanese men without medical history of cardiovascular disease or cancer and investigated the associations of circulating tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and adiponectin with MetS. We used the respective definitions proposed by the National Cholesterol Education Program Adult Treatment Panel III (ATP-III), the International Diabetes Federation, and the Japanese Society of Internal Medicine. Decreased serum adiponectin was observed in those with any of the ATP-III–MetS components, whereas this was not the case with increased TNF-α, IL-6, or CRP. Adiponectin and CRP levels linearly deteriorated with an increasing number of ATP-III–MetS components (trend P P P =0.03; TNF-α: OR, 1.25 [95% CI, 0.94 to 1.67]; P =0.12; and IL-6: OR, 0.87 [95% CI, 0.63 to 1.19]; P =0.37). This result was not altered by using the other 2 criteria. Conclusions— The present results raise the possibility that decreased serum adiponectin might be fundamentally involved in the development of MetS. |
| Databáze: | OpenAIRE |
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