Involvement of major components from Sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis
| Autor: | Marisa Campos Polesi Placeres, Pâmela Alegranci, Lucas Souza Ferreira, Amanda Costa Gonçalves, Danielle Cardoso Geraldo Maia, Alexander Batista-Duharte, Luis Gustavo Silva Monnazzi, Iracilda Zeppone Carlos |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Inflammasomes Veterinary (miscellaneous) Interleukin-1beta Caspase 1 Inflammation Nitric Oxide Applied Microbiology and Biotechnology Microbiology Nitric oxide chemistry.chemical_compound Interferon-gamma Mice Cell Wall medicine Sporothrix schenckii Animals Skin Mice Inbred BALB C Innate immune system biology Sporotrichosis Sporothrix Interleukin-17 Interleukin-18 Inflammasome biology.organism_classification medicine.disease Enzyme Activation Chronic infection chemistry Immunology medicine.symptom Agronomy and Crop Science medicine.drug |
| Zdroj: | Mycopathologia. 179(1-2) |
| ISSN: | 1573-0832 |
| Popis: | Sporotrichosis is a chronic infection caused by the dimorphic fungus Sporothrix schenckii, involving all layers of skin and the subcutaneous tissue. The role of innate immune toll-like receptors 2 and 4 in the defense against this fungus has been reported, but so far, there were no studies on the effect of cell wall major components over the cytosolic oligo-merization domain (NOD)-like receptors, important regulators of inflammation and responsible for the maturation of IL-1β and IL-18, whose functions are dependents of the caspase-1 activation, that can participate of inflammasome. It was evaluated the percentage of activation of caspase-1, the production of IL-1β, IL-18, IL-17, IFN-γ and nitric oxide in a Balb/c model of S. schenckii infection. It was observed a decreased activity of caspase-1 during the fourth and sixth weeks of infection accompanied by reduced secretion of the cytokines IL-1β, IL-18 and IL-17 and high production of nitric oxide. IFN-γ levels were elevated during the entire time course of infection. This temporal reduction in caspase-1 activity coincides exactly with the reported period of fungal burden associated with a transitory immunosuppression induced by this fungus and detected in similar infection models. These results indicate the importance of interaction between caspase-1, cytokines IL-1β and IL-18 in the host defense against S. schenckii infection, suggesting a participation the inflammasome in this response. |
| Databáze: | OpenAIRE |
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