Muscle metabolism in older subjects using 31P magnetic resonance spectroscopy
Autor: | Laurita M. Hack, Roger W. Wheatley, Britton Chance, Todd Goldberg, Mary Ann Forciea, Kevin K. McCully, Carol A. Oatis, Eileen Donlon |
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Rok vydání: | 1991 |
Předmět: |
Adult
Male Aging medicine.medical_specialty Muscle metabolism Magnetic Resonance Spectroscopy Phosphocreatine Physiology Physical exercise Plantar flexion Phosphates Calf muscles chemistry.chemical_compound Adenosine Triphosphate Physiology (medical) Internal medicine medicine Humans Rest (music) Aged Pharmacology Phosphoric Diester Hydrolases Chemistry Muscles Phosphorus Isotopes General Medicine Nuclear magnetic resonance spectroscopy Hydrogen-Ion Concentration Regimen Endocrinology Female |
Zdroj: | Canadian Journal of Physiology and Pharmacology. 69:576-580 |
ISSN: | 1205-7541 0008-4212 |
Popis: | We used phosphorus magnetic resonance spectroscopy to study the calf muscles of elderly normal (mean ± SD) (80.0 ± 5.12 years), elderly impaired (80.7 ± 0.58 years), old normal (66.8 ± 1.92 years), and young normal people (24.6 ± 4.72 years). Relative levels of inorganic phosphate (Pi), phosphocreatine (PCr), and adenosine triphosphate were measured with a 1.9-tesla, 30-cm bore magnet at rest and following plantra flexon exercise. No differences were found at rest or during recovery from exercise in the elderly normal subjects with respect to gender or the presence of stable medical problems treated with medication. At rest there was an age-related decrease in the ratio of PCr/Pi. After exercise, the time constant of PCr recovery increased with age. A mild 7-week exercise regimen consisting of plantar flexion had no effect on time constant of PCr recovery in the elderly subjects. Four elderly impaired subjects had lower PCr/Pi ratios at rest and slower time constant of PCr recovery after exercise than normal elderly subjects. We conclude that gender and the presence of stable medical problems had no effect on muscle metabolism in the elderly and that the elderly recovered slower than young controls. This slower recovery was not corrected with a mild exercise program.Key words: human muscle, aging, exercise, nuclear magnetic resonance, gastrocnemius. |
Databáze: | OpenAIRE |
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