Early Obesity: Risk Factor for Fatty Liver Disease
| Autor: | Florencia De Barbieri, Valeria Cuzmar, Ana Pereira, Ricardo Uauy, Luis Villarroel, Verónica Mericq, José Luis Santos, Cristián García, Camila Corvalán, Gigliola Alberti, Juan Cristóbal Gana |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatric Obesity medicine.medical_specialty Waist Cirrhosis Adolescent medicine.medical_treatment Liver transplantation Gastroenterology 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Risk Factors 030225 pediatrics Internal medicine Nonalcoholic fatty liver disease Prevalence Humans Medicine Longitudinal Studies Chile Child Ultrasonography Anthropometry business.industry Fatty liver nutritional and metabolic diseases medicine.disease Obesity digestive system diseases Liver Child Preschool Pediatrics Perinatology and Child Health Elasticity Imaging Techniques Female 030211 gastroenterology & hepatology business Cohort study |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 70:93-98 |
| ISSN: | 1536-4801 0277-2116 |
| DOI: | 10.1097/mpg.0000000000002523 |
| Popis: | Nonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Fatty liver has become the most frequent indication for liver transplantation in adults. OBJECTIVE The aim of the study was to identify anthropometric variables during the first 10 years of life associated to the risk of developing NAFLD in adolescence. METHODS Longitudinal cohort study 'Growth and Obesity Chilean Cohort Study' (GOCS) consisting of 513 children born in 2002 to 2003, with yearly anthropometric data collected over a 10-year period. The presence of intrahepatic fat in the livers of subjects 14 to 16 years of age was determined using abdominal ultrasound. In addition, elastography was performed on all participants with ultrasound evidence of NAFLD. RESULTS 9.7% of the participants presented findings compatible with NAFLD. After 2 years of age, obesity significantly and progressively increased the probability of NAFLD occurrence in adolescence. Obesity at 5 years of age was associated with the highest OR for NAFLD, reaching values of 8.91 (95% CI 3.03-16.11). Among participants with NAFLD, those with altered liver elasticity (≥7 kPa) had greater weight, BMI z-score, waist and hip circumference, and altered liver enzymes (P |
| Databáze: | OpenAIRE |
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