An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells
| Autor: | William Kim, Alessio Bocedi, Pavel A. Nikitin, Jason P. Tourigny, Martin J. Allday, Katherine Hu, Christopher M. Yan, Jing Guo, Elena Rusyn, Sandeep S. Dave, Amee Patel, Micah A. Luftig, Robert E. White, Eleonora Forte, David M. Tainter |
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| Rok vydání: | 2010 |
| Předmět: |
Herpesvirus 4
Human Cancer Research DNA damage Cell Cell Cycle Proteins Ataxia Telangiectasia Mutated Proteins Biology Protein Serine-Threonine Kinases medicine.disease_cause Microbiology Article Virology hemic and lymphatic diseases Immunology and Microbiology(all) medicine Humans Molecular Biology Cells Cultured Cell Proliferation B-Lymphocytes Cell growth Tumor Suppressor Proteins Cell Transformation Viral Epstein–Barr virus Cell biology DNA-Binding Proteins body regions Checkpoint Kinase 2 medicine.anatomical_structure Viral replication Lytic cycle Epstein-Barr Virus Nuclear Antigens Parasitology Signal transduction Carcinogenesis DNA Damage Signal Transduction |
| Zdroj: | Cell host & microbe |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2010.11.004 |
| Popis: | Evaluation of: Nikitin PA, Yan CM, Forte E et al.: An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. Cell. Host Microbe 8(6), 510-522 (2010). Viruses have evolved elegant strategies to manipulate the host while the host counters with defense systems including the interferon response, apoptosis and the DNA damage response (DDR). Viruses have multiple strategies for manipulating the DDR and the same virus can even activate or inhibit the DDR at different stages of infection. Epstein-Barr virus (EBV) is implicated in several human cancers, including Burkitt's lymphoma, nasopharyngeal carcinoma, post-transplant lymphoproliferative disease and HIV-associated lymphomas. Although multiple viral proteins have been implicated in EBV-associated malignancies, the cellular pathways that control EBV-induced transformation and tumorigenesis remain incompletely understood. In this study, Nikitin et al. demonstrate that early EBV infection induces a cellular DDR that restricts virus-mediated transformation. The EBV-encoded EBNA3C protein subsequently attenuates this response to favor transformation and immortalization of host cells. |
| Databáze: | OpenAIRE |
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