Immunocontraception of white-tailed deer using native and recombinant zona pellucida vaccines
| Autor: | Lowell A. Miller, Gary J. Killian, Brad E. Johns |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Porcine zona pellucida
Swine Enzyme-Linked Immunosorbent Assay Booster dose Odocoileus Antibodies Random Allocation Endocrinology Food Animals Antigen Pregnancy medicine Animals Contraception Immunologic Zona pellucida Progesterone Zona Pellucida Immunocontraception Vaccines biology Deer Vaccination Antibody titer General Medicine biology.organism_classification Virology Recombinant Proteins Titer medicine.anatomical_structure Female Animal Science and Zoology Rabbits Seasons |
| Zdroj: | Animal Reproduction Science. 63:187-195 |
| ISSN: | 0378-4320 |
| DOI: | 10.1016/s0378-4320(00)00177-9 |
| Popis: | We conducted a 2-year feasibility study with native porcine zona pellucida (PZP) vaccine and three recombinant rabbit zona pellucida vaccines (RC55, RC75a and a combination of RC55, RC75a and RC75b) as an initial phase of developing a recombinant immunocontraceptive vaccine to control reproduction in overpopulated herds of white-tailed deer ( Odocoileus virginianus). Forty captive white-tailed does were divided into five groups (one sham and four treated), of eight each and injected with a 500mg prime dose of vaccine. Each prime dose was followed by a 300mg booster dose at 3‐7 weeks post prime. The frequency and number of months of observed breeding were higher in PZP immunized does than in sham controls. Although the antibody titers of the three recombinant groups were 1000 or less, as compared with the PZP group with titers often over 128,000, the fawning rates of the two recombinants were significantly lower than that of the control group. The combined antigen group did not have a significantly lower fawning rate. © 2000 Elsevier Science B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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