Clostridium difficile‐associated diarrhoea: bovine anti‐Clostridium difficile whey protein to help aid the prevention of relapses
| Autor: | Peter Veldkamp, Sandra C Numan, Jaap T. van Dissel, Renate J. van den Berg, Ed J. Kuijper |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Diarrhea Male Whey protein medicine.drug_class Antibiotics Biology Toxin assay Microbiology medicine Secondary Prevention Humans In patient Letters Enterocolitis Pseudomembranous Aged Aged 80 and over Clostridioides difficile Gastroenterology food and beverages Clostridium difficile Middle Aged C difficile Milk Proteins Antibodies Bacterial Whey Proteins Immunology Female medicine.symptom |
| Popis: | Antibiotic treatment can usually help in symptomatic recovery in Clostridium difficile -associated diarrhoea (CDAD), but recurrent episodes of diarrhoea remain a major problem.1–4 Besides increasing the dose or extending the course of antibiotics, and using alternating or pulsed regimens, there are no effective alternatives to prevent relapses.5 Previously, we reported on anti- Clostridium difficile whey protein concentrate (anti-CD-WPC) made from the milk of cows immunised against C difficile and its toxins. Anti-CD-WPC is prepared using standard techniques used in the milk industry, and contains a high concentration of sIgA directed against C difficile and its toxins. It neutralises the cytotoxicity of C difficile toxins in vitro and protects hamsters against otherwise lethal C difficile -associated cecitis.6 The aim of this study was to assess the preliminary efficacy of anti-CD-WPC in aiding the prevention of relapses in patients with CDAD confirmed by positive faecal C difficile toxin assay and … |
| Databáze: | OpenAIRE |
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