The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study
| Autor: | Tuna Semerci, Selcen Yakar Tülüce, Filiz Akyıldız Akçay, Oguzhan Toklu, Erdinç Arıkan, İdil Gökçen Koçağra Yağız, Mehmet Koseoglu, Murat Yeşil, Serdar Bayata |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Randomization Contrast Media Vascular Cell Adhesion Molecule-1 Coronary Artery Disease Coronary Angiography Gastroenterology Iopamidol Angina Pectoris Angina Internal medicine Triiodobenzoic Acids Medicine Humans Clinical significance Prospective Studies Prospective cohort study business.industry Unstable angina Middle Aged medicine.disease Intercellular Adhesion Molecule-1 Iodixanol Cardiology Female Cardiology and Cardiovascular Medicine business Complication medicine.drug |
| Zdroj: | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology. 14(2) |
| ISSN: | 1308-0032 |
| Popis: | OBJECTIVE To compare intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) serum levels between patients with stable (SAP) and unstable angina pectoris (USAP) undergoing coronary angiography (CAG), investigate effects of CAG on ICAM-1, VCAM-1 levels in SAP, USAP patients; probable different effects of non-ionic radiocontrast media (RCM), iso-osmotic iodixanol and low osmolar iopamidol, on these adhesion molecules (AM). METHODS In this randomized, prospective study, 2 groups consisting of patients with SAP (n=22) and USAP (n=22) undergoing CAG were included. For halves of each group iopamidol, for the other halves iodixanol were used as RCM, in turn for randomization. The patients were divided into 4 subgroups according to clinical presentations and used RCM(SAP-iodixanol, SAP-iopamidol USAP-iodixanol, USAP-iopamidol). ICAM-1, VCAM-1 levels were measured just before and 12 hours after CAG. Repeated measurements were compared with two-way ANOVA test. RESULTS Baseline VCAM-1 concentration was higher in USAP group than SAP group (p=0.001). ICAM-1, VCAM-1 concentrations increased significantly following CAG in SAP, USAP groups. ICAM-1, VCAM-1 concentration increments; didn't reach statistical significance in SAP-iodixanol subgroup, reached a borderline significance in SAP-iopamidol subgroup (p=0.06). In USAP-iodixanol subgroup; only VCAM-1 (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|