Identification and analysis of the major metabolites of cocaine in meconium
| Autor: | Shixia Feng, Timothy P. Murphy, Mahmoud A. ElSohly, Wlodzimierz J. Kopycki |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Meconium
Health Toxicology and Mutagenesis Metabolite Toxicology Gas Chromatography-Mass Spectrometry Analytical Chemistry chemistry.chemical_compound Cocaethylene Fetus Cocaine Pregnancy medicine Environmental Chemistry Humans Maternal-Fetal Exchange Immunoassay Chemical Health and Safety Chromatography Chemistry Infant Newborn Norcocaine Substance Abuse Detection Benzoylecgonine Female Gas chromatography–mass spectrometry Ecgonine Quantitative analysis (chemistry) medicine.drug |
| Zdroj: | Journal of analytical toxicology. 23(6) |
| ISSN: | 0146-4760 |
| Popis: | A gas chromatographic-mass spectrometric (GC-MS) method was used for the simultaneous analysis of cocaine and its metabolites (norcocaine, benzoylecgonine, norbenzoylecgonine, ecgonine methylester, cocaethylene, and the o-, m, and p-hydroxy derivatives of cocaine and benzoylecgonine) in meconium specimens collected from newborns prenatally exposed to the drug in an effort to determine which of these metabolites are more relevant in the confirmation of immunoassay-positive specimens. Significant metabolites included benzoylecgonine and its m- and p-hydroxy derivatives. Reanalysis of immunoassay-positive meconium specimens that previously failed to confirm by GC-MS for benzoylecgonine revealed that the GC-MS confirmation rate could be substantially enhanced by inclusion of m- and p-hydroxybenzoylecgonine in the analysis along with benzoylecgonine. Several specimens were found to be positive for hydroxylated derivative(s) in the absence of benzoylecgonine itself. |
| Databáze: | OpenAIRE |
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