Influence of seeds extract of Trigonella foenum graecum (Methi) on mice exposed to gamma radiation
| Autor: | Ranu Chaudhary, K Pradeep Goyal, Uma Gupta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Trigonella
Pharmacology Hematocrit Lipid peroxidation chemistry.chemical_compound medicine lcsh:Nuclear and particle physics. Atomic energy. Radioactivity Irradiation glutathione Safety Risk Reliability and Quality swiss albino mouse medicine.diagnostic_test biology gamma radiation lipid peroxidation Glutathione biology.organism_classification medicine.anatomical_structure Nuclear Energy and Engineering chemistry Distilled water Immunology lcsh:QC770-798 Bone marrow Hemoglobin hematological constituent trigonella foenum graecum |
| Zdroj: | Nuclear Technology and Radiation Protection, Vol 25, Iss 2, Pp 126-132 (2010) |
| ISSN: | 1451-3994 |
| Popis: | The present study has been carried out to evaluate the radioprotective effect of Trigonella foenum seeds extract (TFE) on peripheral blood of mice. For this purpose, mice were orally given double distilled water (control) or optimum dose (100 mg/kg of body weight per day) of TFE for five consecutive days (experimental). Thirty minutes after the last administration of double distilled water or TFE, these were exposed whole-body to 5 Gy gamma radiation and autopsied between 12 hours to 30 days for hematological and biochemical estimation. Total erythrocyte count, hemoglobin level, and hematocrit percentage were decreased from normal in both the groups. A significant increase in these parameters was observed in TFE administered irradiated group, in contrast to without TFE irradiated one, by restoring towards normal values at the end of the experiment. From the results, it is evident that TFE may be responsible for the protection of stem cells in bone marrow which subsequently resulted in higher hematological constituents in peripheral blood. The study concludes the prophylactic use of such plant extract against radiation induced hematological alterations. |
| Databáze: | OpenAIRE |
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