Implantation of Spheramine â in advanced Parkinson's disease (PD)
| Autor: | Cathy D. Raiser, Roy A.E. Bakay, Michael Cornfeldt, Thyagarajan Subramanian, Natividad P. Stover, Richard C. Allen, Alfred W. Schweikert, Ray L. Watts |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Cell Transplantation medicine.medical_treatment Pilot Projects Severity of Illness Index Rating scale medicine Humans In patient Stage (cooking) Pigment Epithelium of Eye business.industry Putamen Parkinson Disease Immunosuppression Middle Aged medicine.disease Microspheres Surgery Transplantation Treatment Outcome Dyskinesia Female medicine.symptom business |
| Zdroj: | Frontiers in Bioscience. 9:592 |
| ISSN: | 1093-4715 1093-9946 |
| DOI: | 10.2741/1217 |
| Popis: | Evaluation of the safety and efficacy of unilateral stereotactic implantation of cultured human retinal pigment epithelial (hRPE) cells attached to microcarriers (Spheramine) in patients with advanced PD in an open label pilot study. Six patients with advanced PD (3 males; 3 females; mean age 52.2 years; mean duration of PD 10.2 years; mean Hoehn and Yahr stage "off" 3.75) were assessed at baseline and post-operatively using the modified CAPIT. Each patient underwent MRI-guided stereotactic transplantation of 325,000 hRPE cells attached to microcarriers in 5 tracts, 5 mm apart in the post-commissural putamen contralateral to the most affected side. Immunosuppression was not used. The UPDRS Motor (UPDR-M) score in the practically defined "off" state was the primary outcome measure. At 6 months post-op, the mean UPDRS-M (off) score improved to 35 (34%) from a pre-op baseline mean of 52 (p |
| Databáze: | OpenAIRE |
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