Rapid drug resistance detection in Mycobacterium tuberculosis: a review of colourimetric methods
| Autor: | Anandi Martin, F Portaels, Juan Carlos Palomino |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Tuberculosis detection review Microbial Sensitivity Tests Drug resistance Antimicrobial resistance Mycobacterium tuberculosis Antibiotic resistance Drug Resistance Bacterial medicine Humans Intensive care medicine Antibacterial agent biology business.industry Isoniazid susceptibility testing General Medicine biology.organism_classification medicine.disease colourimetric methods Multiple drug resistance Infectious Diseases Immunology Colorimetry business Rifampicin medicine.drug |
| Zdroj: | Clinical Microbiology and Infection. 13(8):754-762 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2007.01698.x |
| Popis: | Several new methods to detect drug resistance in Mycobacterium tuberculosis have been proposed in recent years. Colourimetric methods that use redox indicators or the nitrate reduction assay have received increasing attention because of their simplicity and the absence of any requirement for sophisticated equipment or highly trained personnel. Several studies have evaluated their accuracy and performance in comparison with reference standard methods, particularly for the detection of resistance to rifampicin and isoniazid, which are the two most important drugs used for the treatment of tuberculosis. This review describes the development, evaluation and implementation of these methods as rapid alternative tests for the detection of multidrug resistance in M. tuberculosis. Based on published evidence and the high accuracy of colourimetric methods for detecting drug resistance in M. tuberculosis, these methods seem to be appropriate for implementation in high-burden low-resource countries. |
| Databáze: | OpenAIRE |
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