Rare crystalline nephropathy leading to acute graft dysfunction: a case report
| Autor: | Bhavna Bansal, Sahil Bagai, Dinesh Khullar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Graft dysfunction endocrine system Antimetabolites Allopurinol Biopsy Urology Adenine Phosphoribosyltransferase Case Report APRT lcsh:RC870-923 Nephropathy Urolithiasis Internal medicine Medicine Humans Hydrotherapy Kidney medicine.diagnostic_test business.industry Adenine Dihydroxyadenine medicine.disease lcsh:Diseases of the genitourinary system. Urology Kidney Transplantation medicine.anatomical_structure Giant cell Crystalline nephropathy Kidney stones Primary Graft Dysfunction business Crystallization Metabolism Inborn Errors medicine.drug |
| Zdroj: | BMC Nephrology BMC Nephrology, Vol 20, Iss 1, Pp 1-3 (2019) |
| ISSN: | 1471-2369 |
| Popis: | Background Adenine phosphoribosyl transferase (APRT) deficiency is a rare genetic form of kidney stones and/or kidney failure characterized by intratubular precipitation of 2,8 dihydroxyadenine crystals. Early diagnosis and prompt management can completely reverse the kidney injury. Case presentation 44 year old Indian male, renal transplant recipient got admitted with acute graft dysfunction. Graft biopsy showed light brown refractile intratubular crystals with surrounding giant cell reaction, consistent with APRT deficiency. Patient improved after receiving allopurinol and hydration. Conclusion APRT forms a reversible cause of crystalline nephropathy. High index of suspicion is required for the correct diagnosis as timely diagnosis has therapeutic implications. |
| Databáze: | OpenAIRE |
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