Clinical Manifestations, Complications and Treatment of Ocular Sarcoidosis: Correlation between Visual Efficiency and Macular Edema as Seen on Optical Coherence Tomography
| Autor: | Vojislav Sredovic, Predrag Paovic, Jelena Paovic, Svetlana Jovanovic |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Visual acuity medicine.diagnostic_test business.industry General Medicine Disease medicine.disease Dermatology eye diseases 03 medical and health sciences Ophthalmology 0302 clinical medicine Optical coherence tomography Statistical significance Biopsy 030221 ophthalmology & optometry medicine 030212 general & internal medicine Sarcoidosis medicine.symptom business Macular edema Ocular sarcoidosis |
| Zdroj: | Seminars in Ophthalmology. :1-8 |
| ISSN: | 1744-5205 0882-0538 |
| DOI: | 10.1080/08820538.2016.1206576 |
| Popis: | Sarcoidosis is a chronic systemic autoimmune disease which belongs to a group of systemic granulomatous diseases. It can be confirmed through characteristic systemic and ocular manifestations and histological findings. Biopsy is the golden standard for diagnosing sarcoidosis. Ocular sarcoidosis can be confirmed, probable, or possible. Over a two-year period, ocular manifestations were studied on a sample of 52 patients, each followed for four months and diagnosed with some form of systemic sarcoidosis. Most frequent systemic manifestations in patients with ocular sarcoidosis were pulmonary, skin, glandular, and systemic generalized sarcoidosis. The disease was diagnosed four times more frequently in females than males (42:10, respectively; p0.05). Most frequent, and statistically significant, manifestation of ocular sarcoidosis is anterior uveitis (64.61%; p0.01). Macular edema and periphlebitis associated with periarteritis were frequent, and statistically significant (43.90% and 29.26%, respectively; p0.05). Overall, with regards to gender and location (right eye; left eye), visual acuity was0.5 and of statistical significance (76.92%; p0.01). The most common therapy consisted of systemic corticosteroids (26.67%) and/or a combination of corticosteroids and immunosuppressive drugs (23.33%). In 16 eyes treated with repeated doses of sub-Tenon's injections, both initial and control visual acuity correlated with average thickness. There was positive correlation between several optical coherence tomography findings before and after treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|