In vitro antibacterial effect of calcium hydroxide combined with chlorhexidine or iodine potassium iodide on Enterococcus faecalis
| Autor: | E. K. Sirén, Markus Haapasalo, Tuomas Waltimo, Dag Ørstavik |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Disinfectant
Root canal Iodine Compounds chemistry.chemical_element Calcium Iodine Enterococcus faecalis Microbiology Calcium Hydroxide 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine medicine Animals General Dentistry Cells Cultured 030304 developmental biology 0303 health sciences Calcium hydroxide biology Root Canal Irrigants Chlorhexidine 030206 dentistry Fibroblasts biology.organism_classification 3. Good health Drug Combinations medicine.anatomical_structure chemistry Dentin Anti-Infective Agents Local Cattle Antibacterial activity medicine.drug Nuclear chemistry |
| Zdroj: | European journal of oral sciences. 112(4) |
| ISSN: | 0909-8836 |
| Popis: | Several studies have shown a higher success rate of root canal therapy when the canal is free from bacteria at the time of obturation. Treatment strategies that are designed to eliminate this microflora should include agents that can effectively disinfect the root canal. Enterococcus faecalis is often associated with persistent endodontic infections. While in vivo studies have indicated calcium hydroxide to be the most effective all-purpose intracanal medicament, iodine potassium iodide (IKI) and chlorhexidine (CHX) may be able to kill calcium hydroxide-resistant bacteria. Supplementing the antibacterial activity of calcium hydroxide with IPI or CHX preparations was studied in bovine dentine blocks. While calcium hydroxide was unable to kill E. faecalis in the dentine, calcium hydroxide combined with IKI or CHX effectively disinfected the dentine. The addition of CHX or IKI did not affect the alkalinity of the calcium hydroxide suspensions. It may be assumed that combinations also have the potential to be used as long-term medication. Cytotoxicity tests using the neutral red method indicated that the combinations were no more toxic than their pure components. |
| Databáze: | OpenAIRE |
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