Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets

Autor: Jacques R. Bourbon, Bruno Crestani, Jorge Boczkowski, Christophe Delacourt, Olivier Boucherat
Přispěvatelé: PremUp Foundation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Descartes - Paris 5 (UPD5)-CHI Créteil-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre de Recherche en Cancérologie, Université Laval [Québec] (ULaval), Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), O.B. was supported by a postdoctoral fellowship grant from the INSER-FRSQ research exchanges., Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Guellaen, Georges
Jazyk: angličtina
Rok vydání: 2009
Předmět:
MESH: Inflammation
Pathology
medicine.medical_specialty
Apoptosis
Inflammation
Bioinformatics
03 medical and health sciences
0302 clinical medicine
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
medicine
Animals
Humans
MESH: Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Respiratory system
Molecular Biology
MESH: Bronchopulmonary Dysplasia
Cellular Senescence
Premature neonate
Bronchopulmonary Dysplasia
030304 developmental biology
0303 health sciences
Lung
MESH: Humans
MESH: Oxidative Stress
business.industry
MESH: Apoptosis
MESH: Infant
Newborn
Infant
Newborn
medicine.disease
Pathophysiology
3. Good health
Oxidative Stress
medicine.anatomical_structure
Pulmonary Emphysema
030228 respiratory system
Bronchopulmonary dysplasia
MESH: Cell Aging
MESH: Pulmonary Emphysema
Molecular Medicine
medicine.symptom
business
Zdroj: Trends in Molecular Medicine
Trends in Molecular Medicine, Elsevier, 2009, 15 (4), pp.169-79. ⟨10.1016/j.molmed.2009.02.003⟩
Trends in Molecular Medicine, 2009, 15 (4), pp.169-79. ⟨10.1016/j.molmed.2009.02.003⟩
ISSN: 1471-4914
Popis: International audience; Bronchopulmonary dysplasia of the premature neonate and emphysema of the adult lung are common diseases that are characterized by increased airspace size and respiratory insufficiency and that presently lack efficient treatment. Although the former leads to impaired alveolar development and the latter to alveolar destruction, they have striking similarities in their pathophysiology, including the precipitating effect of oxidative stress, sustained inflammation, enhanced apoptosis, protease-antiprotease imbalance, elastic fiber deterioration and altered microvascularization. This review aims to comparatively analyze their molecular mechanisms to try identify common therapeutic targets. The recent discovery that alveolar developmental and maintenance programs share the same signal molecules and pathways, together with considerable increase in their understanding, have facilitated the development of common innovative strategies that have started to be tested in experimental models and pilot clinical studies.
Databáze: OpenAIRE
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