1001 Greater degree of left ventricular scar is associated with increased mortality in patients with severe ischemic cardiomyopathy
| Autor: | Milind Y. Desai, Victoria Zysek, Randolph M. Setser, Deborah H Kwonf, Scott D. Flamm, Zoran B Popovic Paul Schoenhagen, Thomas P. Carrigan, Carmel H Halley, Randall C. Starling |
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| Rok vydání: | 2008 |
| Předmět: |
Medicine(all)
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Ejection fraction Ischemic cardiomyopathy Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Siemens medicine.disease Transplantation Coronary artery disease Flip angle lcsh:RC666-701 Internal medicine Angiography Cardiology Medicine Radiology Nuclear Medicine and imaging Cardiology and Cardiovascular Medicine business Angiology |
| Zdroj: | Journal of Cardiovascular Magnetic Resonance, Vol 10, Iss Suppl 1, p A126 (2008) |
| ISSN: | 1532-429X |
| Popis: | Methods 349 patients with severe ICM >/= 70% coronary artery disease in >/= 1 epicardial vessel on angiography, mean LV ejection fraction (EF) of 24%] that underwent DHE-MRI (Siemens 1.5 T scanner, Erlangen, Germany) from 2003– 6 were studied. (Siemens, Erlangen, Germany) from 2005–6. DHE-MR images were obtained in standard long and short axis orientations (covering the entire LV), after injection of Gadolinium dimenglumine using an inversion recovery spoiled gradient echo sequence: TE 4 msec, TR 8 msec, flip angle 300, bandwidth 140 Hz/pixel, 23 kspace lines acquired every other RR-interval, field of view (varied from 228–330 in the x-direction and 260–330 in the y-direction) and matrix size (varied from 140–180 in the x-direction and 256 in the y-direction). For DHE-MRI analysis, a custom analysis package (VPT software, Siemens, Erlangen, Germany) was used to manually delineate endocardial and epicardial myocardial edges. Scar was defined (as % of myocardium in a 17-segment model on custom software, Siemens Research) on DHE-MR images, as intensity > 2 standard deviation above viable myocardium. Transmurality score was recorded in all segments as follows: 0 = no scar, 1 = 1–25% scar, 2 = 26–50%, 3 = 51– 75% and 4 = > 75%. Total scar score was calculated as transmurality score for all segments/17. LV volumes, EF, demographics, risk factors, need for cardiac transplantation (CTx) and all-cause mortality were recorded. Figure 1. |
| Databáze: | OpenAIRE |
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