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Supplementary Figure S3. (A and B) The graphs compare beta-endorphin levels in the supernatant of oral SCC (HSC-3) cells re-expressing mu-opioid receptor and control oral SCC cells, with and without naloxone treatment. Cells transduced with Ad-OPRM1 at 200 MOI secreted an average of 400pg/ml beta-endorphin, which was significantly higher than non-transduced cells (*p < 0.05, One-way ANOVA, Holm-Sidak test). When treated with naloxone (10-6 to 10-12 mol/L) Ad-OPRM1 HSC-3 cells secreted significantly less beta-endorphin than the control vehicle-treated Ad-OPRM1 HSC-3 cells at all naloxone concentrations (p |
