Impact of chronic endometritis on endometrial receptivity analysis results and pregnancy outcomes
| Autor: | Kazuki Nakao, Keiji Kuroda, Satoru Takamizawa, Yuko Ojiro, Rikikazu Sugiyama, Azusa Moriyama, Takashi Horikawa, Koji Nakagawa, Hiroyasu Juen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Infertility lcsh:Immunologic diseases. Allergy medicine.medical_specialty Immunology Clinical pregnancy Endometrium reproductive failure 03 medical and health sciences 0302 clinical medicine chronic endometritis Pregnancy medicine Immunology and Allergy Humans Pregnancy outcomes Original Research Gynecology business.industry endometrial receptivity analysis Pregnancy Outcome medicine.disease personalized embryo transfer Embryo transfer 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies window of implantation Population study Female Endometrial receptivity business Chronic Endometritis Endometritis infertility lcsh:RC581-607 Infertility Female 030215 immunology |
| Zdroj: | Immunity, Inflammation and Disease, Vol 8, Iss 4, Pp 650-658 (2020) Immunity, Inflammation and Disease |
| ISSN: | 2050-4527 |
| Popis: | Background The aim of this study is to evaluate the relationship between chronic endometritis (CE) and a personalized window of implantation (WOI), identified by results of endometrial receptivity analysis (ERA), and pregnancy outcomes following embryo transfer (ET) based on the ERA outcomes. Methods The single‐center, cross‐sectional study was designed. The study population consisted of 101 infertile women who underwent endometrial sampling between June 2018 and February 2020. We recruited 88 patients who underwent ERA testing and immunohistochemistry of the plasma cell marker CD138 to diagnose CE within 3 months of testing. Subjects were divided into three groups as follows: 33 without CE (non‐CE group); 19 with untreated CE at ERA testing (CE group); and 36 successfully treated for CE before ERA testing (cured‐CE group). CE diagnosis was defined as ≥5 CD138‐positive plasma cells per 10 random stromal areas at ×400 magnification. Results In non‐CE, CE, and cured‐CE groups, the numbers of CD138‐positive cells were 0.7 ± 1.0, 28.5 ± 30.4, and 1.3 ± 1.3, respectively (p To confirm an impact of chronic endometritis (CE) on the results of endometrial receptivity analysis (ERA) testing, subjects were divided into three groups as follows: 33 without CE (non‐CE group); 19 with untreated CE at ERA testing (CE group); and 36 successfully treated for CE before ERA testing (cured‐CE group). The rates of “receptive” endometrium in non‐CE and cured‐CE groups were 57.6% (19 women) and 50.0% (18 women), respectively; however, in the CE group, this rate was significantly lower than the other two groups (p = .009) at only 15.8% (3 women). CE had detrimental effects on the ERA results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |