Synthesis, characterization and antimicrobial activity of (5- bromo-5-nitro-2-oxido-1,3,2-dioxaphosphinan-2-yl)amino acid esters
| Autor: | C H Syama Sundar, P. Santhipriya, C. Suresh Reddy, C. Radha Rani, N. Jagannadha Reddy |
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| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
3-diol 2-bromo-2-nitropropane-1 antifungal activity Two step amino acid ester hydrochlorides General Chemistry dioxaphosphinane Antimicrobial Amino acid lcsh:Chemistry chemistry.chemical_compound antibacterial activity lcsh:QD1-999 chemistry Nitro Organic chemistry Spectral data Antibacterial activity Triethylamine |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 76, Iss 5, Pp 693-698 (2011) |
| ISSN: | 1820-7421 0352-5139 |
| DOI: | 10.2298/jsc100520059s |
| Popis: | Synthesis of a new series of (5-bromo-5-nitro-2-oxido-1,3,2- dioxaphosphinan-2-yl)amino acid esters (3a-l) was accomplished via a two step process, which involves the prior preparation of the monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran in the presence of triethylamine at reflux temperature. The title compounds (3a-l) structures were established by analytical, IR, 1H-, 13C- and 31P-NMR, and mass spectral data. They exhibited significant antibacterial and antifungal activity. |
| Databáze: | OpenAIRE |
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