No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
| Autor: | Ya-Ling Weng, Chih Hsing Wu, Chih-Ting Lee, Jeffrey S. Chang, Yin Fan Chang, Hui-Jen Tsai, Chia Jui Yen, Nai-Jung Chiang, Chia-Rung Tsai, Hui-Chin Liu, Han-Chien Yang, Hsin-En Huang, Ying-Jui Chao, Yan Shen Shan, Li-Tzong Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Alcohol Drinking Science Taiwan Physiology Alcohol Polymorphism Single Nucleotide Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Asian People Pancreatic cancer medicine Humans Genetic Predisposition to Disease Carcinogen ALDH2 Multidisciplinary business.industry Aldehyde Dehydrogenase Mitochondrial Alcohol Dehydrogenase ADH1B Middle Aged medicine.disease Pancreatic Neoplasms Oncology Risk factors chemistry Case-Control Studies 030220 oncology & carcinogenesis Medicine Female 030211 gastroenterology & hepatology Fast activity business Alcohol consumption |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-94111-w |
| Popis: | Inconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic effect of alcohol might have higher pancreatic cancer risk after drinking alcohol. The current study investigated the association between alcohol use and pancreatic cancer with 419 pancreatic cancer cases and 963 controls recruited by a hospital-based case–control study in Taiwan. Gene-environment interaction between alcohol use and polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on pancreatic risk was evaluated. Our results showed no significant association between alcohol drinking and an increased pancreatic cancer risk, even at high levels of alcohol consumption. Even among those genetically susceptible to the carcinogenic effect of alcohol (carriers of ADH1B*2/*2(fast activity) combined with ALDH2*1/*2(slow activity) or ALDH2*2/*2(almost non-functional)), no significant association between alcohol use and pancreatic cancer was observed. Overall, our results suggested that alcohol drinking is not a significant contributor to the occurrence of pancreatic cancer in Taiwan. |
| Databáze: | OpenAIRE |
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