In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles
| Autor: | Muhammad Imran, Shahzad Naseem, Tanzeela Batool, Hera Naheed Khan, Anjum Nasim Sabri, S. Mazhar H. Shah, Saira Riaz |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Sol-Gel
General Chemical Engineering Iron oxide Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Anti-oxidant lcsh:Chemistry chemistry.chemical_compound Tetragonal crystal system ZrO2 Cubic zirconia Ceramic Sol-gel Chemistry Fe3O4 General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Solvent lcsh:QD1-999 visual_art visual_art.visual_art_medium Nanoparticles 0210 nano-technology Hemolytic Iron oxide nanoparticles Nuclear chemistry |
| Zdroj: | Arabian Journal of Chemistry, Vol 13, Iss 11, Pp 7598-7608 (2020) |
| ISSN: | 1878-5352 |
| Popis: | Zirconia ceramics have attained much consideration owing to the amazing mechanical strength and white color. These properties provide an opportunity for the use in biomedical applications. In the present study, an application oriented sol-gel route was adapted for synthesis of zirconia nanoparticles. ZrOCl2·8H2O was used as a precursor, iron oxide (Fe3O4) nanoparticles (pH 2 & pH 9) as a stabilizer and de-ionized water was used as a solvent. Sol-gel synthesized iron oxide stabilized zirconia nanoparticles were prepared by varying concentrations of iron oxide nanoparticles in the range of 2–10 wt%. X-ray diffraction results showed mixed phases at all wt% with acidic pH value, while pure tetragonal phase of zirconia was observed for stabilization with 6 wt% basic iron oxide. Maximum value of dielectric constant (~80 at log f = 4) and minimum value of tangent loss (~0.66 at log f = 4) were observed for zirconia stabilized with basic 6 wt% iron oxide. Maximum value of hardness (1410 ± 10 HV) along with high fracture toughness were observed with optimized stabilization. Very weak hemolytic activity and maximum scavenging (~76) antioxidant activity was observed under optimized conditions. Thus, it can be suggested that optimized nanoparticles, i.e. tetragonal zirconia stabilized with 6 wt% of basic Fe3O4, can be further useful for therapeutical and pharmaceutical applications. |
| Databáze: | OpenAIRE |
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