Exposure of Newborn Rats to Pharmacologically Active Compounds May Permanently Alter Carcinogen Metabolism
| Autor: | TC Campbell, RA Faris |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Aflatoxin Offspring Animal Population Groups Mixed Function Oxygenases Aflatoxins Lactation Internal medicine medicine Animals Oxidase test Multidisciplinary Perinatal Exposure Chemistry Ethylmorphine-N-Demethylase Carcinogen Metabolism Animals Suckling Rats Endocrinology medicine.anatomical_structure Enzyme Induction Phenobarbital Carcinogens Microsomes Liver Microsome Oxidoreductases medicine.drug |
| Zdroj: | Science. 211:719-721 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Administration of phenobarbital to mother rats during early lactation causes long-term, perhaps permanent, alteration of hepatic microsomal mixed-function oxidase activity and aflatoxin B1 adduct formation in the adult male offspring. These findings suggest that perinatal exposure to pharmacologically active compounds may be a determinant of cancer risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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