Trade-offs between gene expression, growth and phenotypic diversity in microbial populations
| Autor: | Alexander P. S. Darlington, Manuel Salvador, José I. Jiménez, José Utrilla, Juhyun Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0303 health sciences Bacteria media_common.quotation_subject fungi Trade offs Biomedical Engineering Cellular functions Gene Expression Bioengineering Computational biology Biology 01 natural sciences Phenotype Article Competition (biology) 03 medical and health sciences 010608 biotechnology Gene expression Resource allocation ComputingMethodologies_COMPUTERGRAPHICS 030304 developmental biology Biotechnology Diversity (business) media_common |
| Zdroj: | Current Opinion in Biotechnology |
| ISSN: | 0958-1669 |
| DOI: | 10.1016/j.copbio.2019.08.004 |
| Popis: | Graphical abstract Highlights • Limitations in molecular resources for gene expression influence bacterial physiology. • Bacteria optimise trade-offs between resource allocation and growth. • Resource allocation plays a role in the emergence of phenotypic heterogeneity. • Trade-offs between bet-hedging and growth can be harnessed in biotechnology. Bacterial cells have a limited number of resources that can be allocated for gene expression. The intracellular competition for these resources has an impact on the cell physiology. Bacteria have evolved mechanisms to optimize resource allocation in a variety of scenarios, showing a trade-off between the resources used to maximise growth (e.g. ribosome synthesis) and the rest of cellular functions. Limitations in gene expression also play a role in generating phenotypic diversity, which is advantageous in fluctuating environments, at the expenses of decreasing growth rates. Our current understanding of these trade-offs can be exploited for biotechnological applications benefiting from the selective manipulation of the allocation of resources. |
| Databáze: | OpenAIRE |
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