Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats
| Autor: | Gerald Bosco Lindoso Couto, Camilla V.N.S. Silva, Luiz Lúcio Soares da Silva, Aldo Cezar Passilongo da Silva, Samuel Daniel de Sousa Filho, Flávia Raquel Santos Lucena, Wilson da Silva Costa-Junior, Jouse Bezerra Cavalcanti, Alex Benício da Silveira, Edvaldo Rodrigues de Almeida, Diógenes Luís da Mota |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Spleen Biology Pharmacology chemistry.chemical_compound Pregnancy Internal medicine Leukocytes medicine Animals Rats Wistar Toxicity Tests Chronic Transaminases Lapachol chemistry.chemical_classification Hematology gamma-Glutamyltransferase Alkaline Phosphatase Teratology Rats Teratogens medicine.anatomical_structure Enzyme Biochemistry chemistry Alkaline phosphatase Female Pyruvic acid Topoisomerase inhibitor Naphthoquinones |
| Zdroj: | Phytotherapy Research. 23:1276-1280 |
| ISSN: | 1099-1573 0951-418X |
| Popis: | Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. beta-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations. |
| Databáze: | OpenAIRE |
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