Blocking of α4β7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques
Autor: | Susan T. Stephenson, Keith A. Reimann, Francois Villinger, Robert H. Lyles, Ann E. Mayne, Xinyue Wang, Yoshiaki Takahashi, Aftab A. Ansari, Andrew A. Price, Rijian Wang, Mohammad Y. Zaidi, Jichu Li, Dawn M. Little |
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Rok vydání: | 2011 |
Předmět: |
Integrins
Integrin beta Chains medicine.drug_class Integrin alpha4 Immunology Cell Simian Acquired Immunodeficiency Syndrome Biology Monoclonal antibody medicine.disease_cause Article Proviruses Intestinal mucosa medicine Gastric mucosa Animals Immunology and Allergy Intestinal Mucosa Antibodies Blocking Vaccines Synthetic Innate immune system Viral Load Simian immunodeficiency virus Macaca mulatta Virology Protein Transport medicine.anatomical_structure Gastric Mucosa Acute Disease DNA Viral Injections Intravenous Simian Immunodeficiency Virus Viral load Homing (hematopoietic) |
Zdroj: | The Journal of Immunology. 186:1044-1059 |
ISSN: | 1550-6606 0022-1767 |
Popis: | Intravenous administration of a novel recombinant rhesus mAb against the α4β7 gut-homing integrin (mAb) into rhesus macaques just prior to and during acute SIV infection resulted in significant decrease in plasma and gastrointestinal (GI) tissue viral load and a marked reduction in GI tissue proviral DNA load as compared with control SIV-infected rhesus macaques. This mAb administration was associated with increases in peripheral blood naive and central memory CD4+ T cells and maintenance of a high frequency of CCR5+CD4+ T cells. Additionally, such mAb administration inhibited the mobilization of NK cells and plasmacytoid dendritic cells characteristically seen in the control animals during acute infection accompanied by the inhibition of the synthesis of MIP-3α by the gut tissues. These data in concert suggest that blocking of GI trafficking CD4+ T cells and inhibiting the mobilization of cell lineages of the innate immune system may be a powerful new tool to protect GI tissues and modulate acute lentiviral infection. |
Databáze: | OpenAIRE |
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