Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial

Autor: Florence Brugnon, Joël R. Drevet, Anne-Sophie Gremeau, Bruno Pereira, Laurent Janny, Igor Tauveron, Benoit Sion, Geneviève Grizard, Hanae Pons-Rejraji, Salwan Maqdasy, Geoffroy Marceau, Gerald Gouby
Přispěvatelé: Génétique, Reproduction et Développement (GReD), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire BDR CECOS - FIV AMP, CHU Estaing [Clermont-Ferrand], Neuro-Dol (Neuro-Dol), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Délégation à la Recherche Clinique et à l'Innovation (DRCI), CHU Clermont-Ferrand, service de Biostatistiques, DRCI, Centre Hospitalier Universitaire de Clermont-Ferrand, Laoratoire de Biochimie, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Unité de Biostatistiques [CHU Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Service d'Endocrinologie-Diabétologie, CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Laboratoires d'Hématologie et de Biochimie, Hôtel-Dieu-CHU Clermont-Ferrand-Université d'Auvergne - Clermont-Ferrand I (UdA), This study was supported by a local hospital grant from the Hospital Clinical Research Program of the French Ministry of Health (PHRC L 06 Tauveron), and the DRCI of Clermont-Ferrand university hospital. The authors thank Elizabeth Petit and Dr. Christine Rondanino for revising the English language., Autard, Delphine
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
[SDV]Life Sciences [q-bio]
Atorvastatin
Pilot Projects
[SDV.GEN] Life Sciences [q-bio]/Genetics
chemistry.chemical_compound
Endocrinology
Testis
Testosterone
[SDV.BDD]Life Sciences [q-bio]/Development Biology
ComputingMilieux_MISCELLANEOUS
[SDV.BDD.GAM]Life Sciences [q-bio]/Development Biology/Gametogenesis
Epididymis
[SDV.BA]Life Sciences [q-bio]/Animal biology
Prostate
Obstetrics and Gynecology
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Spermatozoa
3. Good health
Cholesterol
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
Asthenozoospermia
Healthy men
lipids (amino acids
peptides
and proteins)
Gonadal Hormones
medicine.drug
Adult
medicine.medical_specialty
Statin
medicine.drug_class
Down-Regulation
Context (language use)
Semen
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Antispermatogenic Agents
Normocholesterolemic
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Biology
[SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction
Young Adult
Semen quality
Internal medicine
medicine
Humans
Pyrroles
Seminal fluid
Spermatogenesis
[SDV.GEN]Life Sciences [q-bio]/Genetics
Acrosome Reaction
Research
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology
medicine.disease
Reproductive Medicine
chemistry
Heptanoic Acids
Normozoospermic
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Biomarkers
Gonadotropins
Human Spermatozoa
Developmental Biology
Hormone
Zdroj: Reproductive Biology and Endocrinology
Reproductive Biology and Endocrinology, BioMed Central, 2014, 12 (1), ⟨10.1186/1477-7827-12-65⟩
Reproductive Biology and Endocrinology, BioMed Central, 2014, 12 (1), pp.65. ⟨10.1186/1477-7827-12-65⟩
Reproductive Biology and Endocrinology : RB&E
Reprod Biol Endocrinol
Reprod Biol Endocrinol, 2014, 12, pp.65. ⟨10.1186/1477-7827-12-65⟩
ISSN: 1477-7827
Popis: International audience; BACKGROUND: Recommendations for cardiovascular disease prevention advocate lowering both cholesterol and low-density lipoprotein cholesterol systemic levels, notably by statin intake. However, statins are the subject of questions concerning their impact on male fertility. This study aimed to evaluate, by a prospective pilot assay, the efficacy and the toxicity of a decrease of cholesterol blood levels, induced by atorvastatin on semen quality and sexual hormone levels of healthy, normocholesterolaemic and normozoospermic men. METHODS: Atorvastatin (10 mg daily) was administrated orally during 5 months to 17 men with normal plasma lipid and standard semen parameters. Spermatozoa parameters, accessory gland markers, semen lipid levels and blood levels of gonadal hormones were assayed before statin intake, during the treatment, and 3 months after its withdrawal. RESULTS: Atorvastatin treatment significantly decreased circulating low-density lipoprotein cholesterol (LDL-C) and total cholesterol concentrations by 42% and 24% (p
Databáze: OpenAIRE
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