Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group
| Autor: | Sean N. Hatton, Paul M. Thompson, Dominik Grotegerd, Tilo Kircher, Dilara Yüksel, Jair C. Soares, Emma L. Hawkins, Elena Filimonova, Maria J. Portella, Beata R. Godlewska, Jeanne Leerssen, Matthew D. Sacchet, Ole A. Andreassen, Christopher R.K. Ching, Ian H. Gotlib, Ronny Redlich, Axel Krug, Benson Mwangi, Evgeny Osipov, Mathew A. Harris, Angela Carballedo, Eus J.W. Van Someren, Natalia Jaworska, Oliver Gruber, Janik Goltermann, Katharina Dohm, Verena Enneking, Udo Dannlowski, Elena Pozzi, Lianne Schmaal, Tessa F. Blanken, Ivan Brack, Dick J. Veltman, Neda Jahanshad, Igor Nenadic, Lyubomir I. Aftanas, Jim Lagopoulos, Frank P. MacMaster, Ian B. Hickie, Heather C. Whalley, Egle Simulionyte, Stella M Fingas, Bernhard T. Baune, Quinn McLellan, Martin Walter, Susanne Meinert, Jonathan Repple, Thomas Frodl, Hannah Lemke, Meng Li, Andrew M. McIntosh, Norio Watanabe, Philipp G. Sämann |
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| Přispěvatelé: | Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Netherlands Institute for Neuroscience (NIN), Integrative Neurophysiology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Adolescent Posterior parietal cortex macromolecular substances Audiology behavioral disciplines and activities Article lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult 0302 clinical medicine SDG 3 - Good Health and Well-being Sleep Initiation and Maintenance Disorders Human behaviour mental disorders medicine Humans Bipolar disorder Young adult Risk factor lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Depression (differential diagnoses) Aged Cerebral Cortex Depressive Disorder Major business.industry Depression Brain Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure nervous system Cerebral cortex Major depressive disorder Orbitofrontal cortex business 030217 neurology & neurosurgery |
| Zdroj: | Translational psychiatry, 10(1):425 Translational Psychiatry 2020, ' Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group ', Translational Psychiatry, vol. 10, no. 1 . https://doi.org/10.1038/s41398-020-01109-5 Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020) Translational Psychiatry, 10(1). Nature Publishing Group Leerssen, J, Blanken, T F, Pozzi, E, Jahanshad, N, Aftanas, L, Andreassen, O A, Baune, B T, Brack, I, Carballedo, A, Ching, C R K, Dannlowski, U, Dohm, K, Enneking, V, Filimonova, E, Fingas, S M, Frodl, T, Godlewska, B R, Goltermann, J, Gotlib, I H, Grotegerd, D, Gruber, O, Harris, M A, Hatton, S N, Hawkins, E, Hickie, I B, Jaworska, N, Kircher, T, Krug, A, Lagopoulos, J, Lemke, H, Li, M, MacMaster, F P, McIntosh, A M, McLellan, Q, Meinert, S, Mwangi, B, Nenadić, I, Osipov, E, Portella, M J, Redlich, R, Repple, J, Sacchet, M D, Sämann, P G, Simulionyte, E, Soares, J C, Walter, M, Watanabe, N, Whalley, H C, Yüksel, D, Veltman, D J, Thompson, P M, Schmaal, L & van Someren, E J W 2020, ' Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group ', Translational psychiatry, vol. 10, no. 1, 425 . https://doi.org/10.1038/s41398-020-01109-5 Translational Psychiatry, 10:425, 1-11. Nature Publishing Group Leerssen, J, Blanken, T F, Pozzi, E, Jahanshad, N, Aftanas, L, Andreassen, O A, Baune, B T, Brack, I, Carballedo, A, Ching, C R K, Dannlowski, U, Dohm, K, Enneking, V, Filimonova, E, Fingas, S M, Frodl, T, Godlewska, B R, Goltermann, J, Gotlib, I H, Grotegerd, D, Gruber, O, Harris, M A, Hatton, S N, Hawkins, E, Hickie, I B, Jaworska, N, Kircher, T, Krug, A, Lagopoulos, J, Lemke, H, Li, M, MacMaster, F P, McIntosh, A M, McLellan, Q, Meinert, S, Mwangi, B, Nenadić, I, Osipov, E, Portella, M J, Redlich, R, Repple, J, Sacchet, M D, Sämann, P G, Simulionyte, E, Soares, J C, Walter, M, Watanabe, N, Whalley, H C, Yüksel, D, Veltman, D J, Thompson, P M, Schmaal, L & Van Someren, E J W 2020, ' Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder : results from the ENIGMA MDD Working Group ', Translational Psychiatry, vol. 10, 425, pp. 1-11 . https://doi.org/10.1038/s41398-020-01109-5 |
| ISSN: | 2158-3188 |
| Popis: | It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD. |
| Databáze: | OpenAIRE |
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