Cross-reactive cytotoxic responses. H-2 restricted are more specific than anti-H-2 responses
| Autor: | C. M. Hetherington, P R Chandler, M Hurme, C Brunner, L E Mobraaten, D W Bailey, E Simpson |
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| Rok vydání: | 1978 |
| Předmět: |
Cytotoxicity
Immunologic Graft Rejection Male Isoantigens T-Lymphocytes Lymphocyte H-Y Antigen Immunology Mutant Cross Reactions Biology Major histocompatibility complex Mice Tissue culture Antigen medicine Animals Immunology and Allergy Cytotoxic T cell Cytotoxicity Gene H-2 Antigens Articles medicine.anatomical_structure biology.protein Female Lymphocyte Culture Test Mixed Immunologic Memory |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Cross-reactive T-cell cytotoxicity is seen when cytotoxic responses are generated in mixed lymphocyte cultures either between mouse strans which differ at the major histocompatibility complex, H-2, or between H-2b mutant strains and the strain from which they were derived. This cross-reactivity can be measured with [51Cr] labeled target cells from a number of different H-2 haplotypes, and the pattern of cross-reaction indicates that the target antigens are unlikely to be any of the serologically defined public specificities. In contrast, the specificity of H-2 restricted cytotoxic responses, such as that to the male-specific antigen, H-Y, is exquisite, and male cells from strains of mice carrying H-2 haplotypes other than the responder have never been found to act as appropriate targets. The contrast between the specificity of anti-H-2 and H-2 restricted responses may argue for a greater idiotypic homogeneity of the cells makiing H-2 restricted responses, and the greater specificity of these responses may be necessary for their biological function. |
| Databáze: | OpenAIRE |
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