Parasiticidal effect of 16α-bromoepiandrosterone (EpiBr) in amoebiasis and cysticercosis
Autor: | Chris Reading, Charles Dowding, Julio César Carrero, Claudia Cervantes-Rebolledo, Jorge Morales-Montor, Romel Hernández-Bello, James M. Frincke, José Antonio Vargas-Villavicencio |
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Rok vydání: | 2010 |
Předmět: |
Male
Cell Survival Liver Abscess Immunology Antiprotozoal Agents Helminthiasis Androsterone Microbiology Parasite load Mice Entamoeba histolytica In vivo Cricetinae parasitic diseases medicine Animals Amoebiasis Anthelmintics Taenia crassiceps Taenia biology Cysticercosis Histocytochemistry Amebiasis medicine.disease biology.organism_classification Survival Analysis Infectious Diseases Protozoa Female Locomotion |
Zdroj: | Microbes and Infection. 12:677-682 |
ISSN: | 1286-4579 |
Popis: | The effect of the dehydroepiandrosterone analog 16alpha-bromoepiandrosterone (EpiBr) was tested on the tapeworm Taenia crassiceps and the protist Entamoeba histolytica, both in vivo and in vitro. Administration of EpiBr prior to infection with cysticerci in mice reduced the parasite load by 50% compared with controls. EpiBr treatment induced 20% reduction on the development of amoebic liver abscesses in hamsters. In vitro treatment of T. crassiceps and E. histolytica cultures with EpiBr, reduced reproduction, motility and viability in a dose- and time-dependent fashion. These results leave open the possibility of assessing the potential of this hormonal analog as a possible anti-parasite drug, including cysticercosis and amoebiasis. |
Databáze: | OpenAIRE |
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