Push and Pull Forces in Lipid Raft Formation: The Push Can Be as Important as the Pull
| Autor: | Martin R. Krause, Steven L. Regen, Chang Wang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Chemistry
Stereochemistry Lipid raft formation Context (language use) General Chemistry Biochemistry Catalysis Biomechanical Phenomena Domain formation Membrane Microdomains Colloid and Surface Chemistry Phase (matter) Push and pull Phosphatidylcholines Biophysics lipids (amino acids peptides and proteins) Dimerization Lipid raft Mechanical Phenomena |
| Zdroj: | Journal of the American Chemical Society. 137:664-666 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja5115437 |
| Popis: | Nearest-neighbor recognition measurements have been made using exchangeable mimics of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine in the liquid-ordered (lo) and liquid-disordered (ld) states. In the ld phase, the net interaction between these two lipids is repulsive. In the lo phase, their interactions are neither attractive nor repulsive. These results, together with previous nearest-neighbor measurements, imply that the overall driving force for lipid domain formation in bilayers composed of high-melting lipids, low-melting lipids, and cholesterol, corresponds to a strong pull (attraction) between the high-melting lipids and cholesterol, a significant push (repulsion) between the low-melting and high-melting lipids, and a significant push between the low-melting lipids and cholesterol. In a broader context, these results provide strong support for the notion that repulsive forces play a major role in the formation of lipid rafts. |
| Databáze: | OpenAIRE |
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