Keratinocyte Expression of MHC Class II Antigens in Allergic Sensitization and Challenge Reactions and in Irritant Contact Dermatitis
| Autor: | K. Guy, Mary M. Carr, J.A.A. Hunter, Eva McVittie, D.J. Gawkrodger |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Dermatology Major histocompatibility complex Dermatitis Contact Biochemistry 2 4-Dinitrochlorobenzene Allergic sensitization Immunoenzyme Techniques chemistry.chemical_compound Antigen Nickel medicine Dinitrochlorobenzene Humans Allergic contact dermatitis Molecular Biology Sensitization Skin Inflammation biology Histocompatibility Antigens Class II Cell Biology Anthralin Middle Aged medicine.disease medicine.anatomical_structure chemistry Immunology Irritant contact dermatitis biology.protein Irritants Female Keratinocyte |
| Zdroj: | Journal of Investigative Dermatology. 88(1):11-16 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12464641 |
| Popis: | Keratinocytes expressed major histocompatibility complex class II antigens during the development of irritant contact dermatitis, and during the induction of contact hypersensitivity, as well as in established allergic contact dermatitis. A battery of anti-class II monoclonal antibodies, some of which are specific for class II subregion products (DP, DQ, DR), was used in an immunohistochemical study of the sequential changes in the allergic challenge reactions to dinitrochlorobenzene (DNCB) and nickel, the irritant response to anthralin, and the induction of sensitization to DNCB. The induction of keratinocyte class II expression paralleled the influx of Leu-3a+ T cells into the skin and had occurred by 24 or 48 h in each type of reaction. Differential expression of class II subregion products on keratinocytes was noted: DR was the most frequently expressed molecule, followed by DP and DQ, although in the irritant response, DP expression was not observed. The importance of these observations can be decided only by functional studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|