| Autor: |
Sebastian Gonzalez-Dambrauskas, Pablo Vasquez-Hoyos, Anna Camporesi, Edwin Mauricio Cantillano, Samantha Dallefeld, Jesus Dominguez-Rojas, Conall Francoeur, Anar Gurbanov, Liliana Mazzillo-Vega, Steven L. Shein, Adriana Yock-Corrales, Todd Karsies, Ryan Nofziger, Shashikanth Ambati, Tanil Kendirli, Ronald Sanders, Lee Polikoff, Siobhan Whelan, Francisca Castro, Claudia Beltrán, Rosalba Pardo, Gonzalo Vega, Mauricio Yunge, Lorena Acevedo, Ivan Jose Ardila, Diego Aranguiz, MarthaI Alvarez-Olmos, Jaime Fernandez-Sarmiento, Arieth Figueroa-Vargas, Maribel Valencia-Benavides, Juan David Roa, Rubén Lasso-Palomino, Alessia Franceschi, Carina Venthur, Camila Ampuero, Jhovana E. Paco-Barral, Jaime Tasayco-Muñoz, Jesús Domínguez-Rojas, Francisca Rafael-Patricio, Solana Pellegrini, Marcela Zuazaga, Silvana Brusca, Marisa Viera, Vladmir Ivan Aguilera-Avendano, F. Alejandro, L. Martínez, E. Thelma, M. Terán, Mariela Coronado-Lujan, Fabiola Castro-Mancilla, Franco Diaz-Rubio, Karina Cinquegrana, Alicia Sandoval, Andrea Gonzalez, Marta Zamora, Yurika Lopez-Alarcon, María Slöcker-Barrio, Javier Urbano-Villaescusa, Humberto Camacho, Liliana Mazzillo, Beatriz Giraldo, Pitas Suarez, Miguel Cespedes-Lesczinsky, Jorge Omar Castillo, Juan Pablo Fabris, Carolina Paladino, Silvia Sanabria, Erika Urena-Chavarría, Gaudi Quispe, Manuel Munaico-Abanto, Miriam Colombo, Ana Carola Blanco, Byron Enrique Pineres-Olave, Ricardo Carvajal-Veas, Patricia Correa, Ricardo Garcia-De-Jesus, Arani Ferre, Pietro Pietroboni, Edwin Mauricio-Cantillano, Linda Banegas-Pineda, Nils Casson-Rodriguez, Agustin Cavagnaro, Adriana Wegner, Eliana Zemanate, Emilce Beltran-Zuñiga, Maria Alejandra Suarez, Deyanira Quiñonez, Leonardo Valero, Alejandra Repetur, Pablo Castellani, Adriana Bordogna, Alfredo De-la-Hoz-Pastor, Evelyn Obando-Belalcazar, Andrew Prout, Roberto Jabornisky, Andy Wen, Bria Coates, Christopher Watson, Elizabeth Mack, Jahee Hong, Steven Pon, Heda Dapul, Steven Shein, Murat Kangin, Shira Gertz, Laurence Ducharme-Crevier, Ilana Harwayne-Gidansky, Marisol Fonseca-Flores, Juan Carlos Nunez-Enriquez, Armando Leon-Villanueva, Ledys Maria, Teddy Muisyo, Michael Spaeder |
| Rok vydání: |
2022 |
| Zdroj: |
Lancet regional health. Americas. 12 |
| ISSN: |
2667-193X |
| Popis: |
To understand critical paediatric coronavirus disease 2019 (COVID-19) and evaluate factors associated with mortality in children from high and low-middle income countries.Prospective, observational study of critically ill children hospitalised for COVID-19 in 18 countries throughout North America, Latin America, and Europe between April 1 and December 31, 2020. Associations with mortality were evaluated using logistic regression.557 patients (median age, 8 years; 24%2 years) were enrolled from 55 sites (63% Latin American). Half had comorbidities. Invasive (41%) or non-invasive (20%) ventilation and vasopressors (56%) were the most common support modalities. Hospital mortality was 10% and higher in children2 years old (15%; odds ratio 1·94, 95%CI 1·08-3·49). Most who died had pulmonary disease. When adjusted for age, sex, region, and illness severity, mortality-associated factors included cardiac (aOR 2·89; 95%CI 1·2-6·94) or pulmonary comorbidities (aOR 4·43; 95%CI 1·70-11·5), admission hypoxemia (aOR 2·44; 95%CI 1·30-4·57), and lower respiratory symptoms (aOR 2·96; 95%CI 1·57-5·59). MIS-C (aOR 0·25; 95%CI 0·1-0·61) and receiving methylprednisolone (aOR 0·5; 95%CI 0·25-0·99), IVIG (aOR 0·32; 95%CI 0·16-0·62), or anticoagulation (aOR 0·49; 95%CI 0·25-0·95) were associated with lower mortality although these associations might be limited to children2 years old.We identified factors associated with COVID-19 mortality in critically ill children from both high and low-middle income countries, including higher mortality with younger age and COVID-related pulmonary disease but lower mortality in MIS-C. Further research is needed on optimal treatments for younger children and respiratory failure in paediatric COVID-19.None. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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