Coxsackievirus B4 and type 1 diabetes pathogenesis: contribution of animal models
| Autor: | Didier Hober, Famara Sane, M. B. Romond, Mahjoub Aouni, Hela Jaïdane, Jawhar Gharbi |
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| Rok vydání: | 2009 |
| Předmět: |
Type 1 diabetes
biology Endocrinology Diabetes and Metabolism Coxsackievirus Infections Context (language use) Nod Coxsackievirus medicine.disease biology.organism_classification medicine.disease_cause Enterovirus B Human Rats Pathogenesis Disease Models Animal Mice Diabetes Mellitus Type 1 Endocrinology Diabetes mellitus Immunology Internal Medicine Genetic predisposition medicine Animals Humans Enterovirus |
| Zdroj: | Diabetes/Metabolism Research and Reviews. 25:591-603 |
| ISSN: | 1520-7560 1520-7552 |
| Popis: | The role of enteroviruses, in particular type B coxsackieviruses (CV-B), in type 1 diabetes (T1D) pathogenesis is supported by epidemiological, clinical and experimental observations.The investigation of T1D pathogenesis benefits from the contribution of animal models called spontaneously diabetic. Among these animals the non-obese diabetic (NOD) mouse and the bio-breeding diabetes-prone (BBDP) rat present a genetic susceptibility manifested by the expression of an autoimmune diabetes similar to the pathology observed in human beings. Other models whose genetic predisposition is less known are of considerable contribution as well. Numerous major observations relative to several aspects of T1D pathogenesis in the context of CV-B infections, such as susceptibility, diabetogenicity, pancreatotropism, mechanisms of beta cells destruction and others, have been deduced thanks to investigations with animal models. Despite their limits, these models are necessary in improving our knowledge of the role of enteroviruses, like CV-B4, in the pathogenesis of T1D, and the recent advances ensuing from their contribution may have important therapeutic and preventive spin-offs. |
| Databáze: | OpenAIRE |
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