Synthesis of 64CuII–Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual-Modality PET–MRI Agent**
| Autor: | Arnaud Glaria, Philip J. Blower, Istvan Szanda, Rowena L. Paul, Rafael Torres Martin de Rosales, Richard Tavaré, Andrea Protti, Gopal Varma, Maite Jauregui-Osoro |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Superparamagnetic iron oxide nanoparticles
Organophosphonates Contrast Media 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis Mice Nuclear magnetic resonance In vivo Coordination Complexes medicine Medical imaging Organometallic Compounds Animals Magnetite Nanoparticles Chelating Agents rare earths medicine.diagnostic_test Chemistry Communication Magnetic resonance imaging Dextrans General Chemistry 021001 nanoscience & nanotechnology Magnetic Resonance Imaging 3. Good health 0104 chemical sciences chelates imaging agents Copper Radioisotopes Positron emission tomography copper Positron-Emission Tomography Dual modality nanoparticles Tomography Lymph Nodes 0210 nano-technology Preclinical imaging |
| Zdroj: | Angewandte Chemie (International Ed. in English) |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | The synergistic combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) is likely to become the next generation of dual-modality scanners in medical imaging. These instruments will provide us with accurate diagnoses thanks to the sensitive and quantifiable signal of PET and the high soft-tissue resolution of MRI. Furthermore, patients will receive less radiation dose and spend less time in the procedure relative to current dual-modality scanners (e.g. PET–computed tomography (CT)). As a consequence, there has been increasing interest recently in the development of dual-modality PET–MRI agents.[1] |
| Databáze: | OpenAIRE |
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