| Autor: |
Liam G Heaney, David Price, Tom Brown, Paddy Dennison, Robin Gore, Andrew Menzies-Gow, Mitesh Patel, Robert A. Stone, Simon D. Message, John Busby, Adel H. Mansur, Paul E Pfeffer, Robert Niven, Salman Siddiqui, Rekha Chaudhuri, David A. Jackson, UK Severe Asthma Registry |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Busby, J, Heaney, L, Brown, T, Chaudhuri, R, Dennison, P, Gore, R, Jackson, D J, Mansur, A H, Menzies-Gow, A N, Message, S, Niven, R, Patel, M, Price, D, Siddiqui, S, Stone, R & Pfeffer, P 2022, ' Ethnic Differences in Severe Asthma Clinical Care and Outcomes: An Analysis of United Kingdom Primary and Specialist Care ', The journal of allergy and clinical immunology. In practice, vol. 10, no. 2, pp. 495-505 . https://doi.org/10.1016/j.jaip.2021.09.034 |
| ISSN: |
2213-2198 |
| DOI: |
10.1016/j.jaip.2021.09.034 |
| Popis: |
Background Understanding the effects of ethnicity in severe asthma is important for optimal personalized patient care. Objective To assess ethnic differences in disease control, exacerbations, biological phenotype, and treatment in severe asthma in the United Kingdom. Methods We compared demographics, type 2 biomarkers, lung function, asthma control, medications, and health care use between White and underrepresented ethnic group patients in the UK Severe Asthma Registry (UKSAR) and Optimum Patient Care Research Database (OPCRD). Results A total of 3637 patients (665 from the underrepresented ethnic group) were included from UKSAR and 10,549 (577 from the underrepresented ethnic group) from OPCRD. Patients in the underrepresented ethnic group had higher levels of uncontrolled disease when measurements were made using the asthma control questionnaire in UKSAR (odds ratio [OR] = 1.47; 95% confidence interval [CI], 1.12-1.93) and the Royal College of Physicians 3 Questions in OPCRD (OR = 1.82; 95% CI, 1.27-2.60). Although exacerbation rates were similar, patients in the underrepresented ethnic group were more likely to have recently attended the emergency department (OR = 1.55; 95% CI, 1.26-1.92) or to have been hospitalized (OR = 1.31; 95% CI, 1.07-1.59) owing to asthma. Inflammatory biomarkers were consistently higher in the underrepresented ethnic group, including blood eosinophils in OPCRD (ratio = 1.12; 95% CI, 1.05-1.20) and in UKSAR blood eosinophils (ratio = 1.16; 95% CI, 1.06-1.27), FeNO (ratio = 1.14; 95% CI, 1.04-1.26), and IgE (ratio = 1.70; 95% CI, 1.47-1.97). Patients in the underrepresented ethnic group were more likely to be atopic in the UKSAR (OR = 1.32; 95% CI, 1.07-1.63) and OPCRD (OR = 1.67; 95% CI, 1.26-2.21), and less likely to be using maintenance oral corticosteroids at referral (OR = 0.75; 95% CI, 0.61-0.92). Conclusions Severe asthma patients from underrepresented ethnic groups presented with a higher disease burden and were more likely to attend the emergency department. They had a distinct phenotypic presentation and differences in medicine use, with higher levels of type 2 biomarkers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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