Rheological analyses of coagulation of blood from different individuals with special reference to procoagulant activity of erythrocytes
| Autor: | Makoto Kaibara, Hiroki Iwata, Manabu Kaibara, Ryutaro Himeno, Hiroshi Ujiie |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Time Factors Factor IX chemistry.chemical_compound Internal medicine medicine Humans Platelet Blood Coagulation Whole blood Aged Aged 80 and over Chemistry Factor X Serine Endopeptidases Age Factors Hematology General Medicine Middle Aged Red blood cell Membrane medicine.anatomical_structure Endocrinology Coagulation Biochemistry Hematocrit Hemorheology Female medicine.drug |
| Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 16(5) |
| ISSN: | 0957-5235 |
| Popis: | In our previous papers, we reported that factor IX (FIX), when activated by erythrocyte membranes, causes coagulation. We have identified and characterized the FIX-activating enzyme located in normal human erythrocyte membranes. In this paper, to examine physiological and pathological significances of procoagulant activity of erythrocytes, coagulation of blood obtained from different individuals was analyzed by means of a rheological technique. In more than 65% of subjects including normals and patients, the initiation of coagulation seemed to be governed by erythrocytes. Coagulation of whole blood and platelet-free plasma supplemented with erythrocytes had a tendency to occur rapidly in the elderly. It was suggested that the concentration of FIX-activating enzyme on erythrocyte membranes for aged donors was somewhat higher than that for young ages. Propagation reactions on erythrocyte membranes (i.e. factor X activation leading to thrombin generation after FIX activation) was slower than that on platelet membranes. Moreover, the propagation reaction on erythrocyte membranes was greatly dependent on individuals, whereas that on platelet membranes was not so much. Our study demonstrates that the activation of FIX by erythrocytes and subsequent propagation reaction on platelet membranes may be important for initiating and controlling blood coagulation reactions. |
| Databáze: | OpenAIRE |
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