Antiretroviral therapy affects the z-score index of deviant cortical EEG rhythms in naïve HIV individuals
| Autor: | Lorenzo Ciullini, Susanna Lopez, Susanna Cordone, Paolo Roma, Francesco Di Campli, Stefano Ferracuti, Cristina Limatola, Massimo Andreoni, Ketura Berry, Chiara Muratori, Valentina Correr, Andrea Soricelli, Antonio Aceti, Paolo Capotosto, Alfredo Pennica, Magdalena Viscione, Elisabetta Teti, Claudio Del Percio, Paolo Onorati, Laura Gianserra, Claudio Babiloni, Giuseppe Noce |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Neurology Human immunodeficiency virus (HIV) HIV Infections Alpha rhythms Delta rhythms Low-resolution brain electromagnetic source tomography (LORETA) Resting-state electroencephalography (EEG) z-Score Electroencephalography Audiology medicine.disease_cause lcsh:RC346-429 0302 clinical medicine Antiretroviral Therapy Highly Active Nuclear Medicine and Imaging Beta Rhythm Cerebral Cortex medicine.diagnostic_test 05 social sciences virus diseases Regular Article Alpha Rhythm lcsh:R858-859.7 Psychology Radiology Adult Cart medicine.medical_specialty Settore MED/17 - Malattie Infettive Cognitive Neuroscience Standard score Neurology (clinical) Radiology Nuclear Medicine and Imaging lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences Rhythm mental disorders medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system alpha rhythms delta rhythms human immunodeficiency virus (HIV) low-resolution brain electromagnetic source tomography (LORETA) Brain Waves Antiretroviral therapy Delta Rhythm Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 12, Iss C, Pp 144-156 (2016) NeuroImage : Clinical |
| Popis: | Objective Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. Methods Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual. They also included beta1 (13–20 Hz) and beta2 (20–30 Hz). Low-resolution brain electromagnetic tomography (LORETA) estimated EEG cortical source activity in frontal, central, temporal, parietal, and occipital regions. Results Before the therapy, the HIV group showed greater parietal delta source activity and lower spatially diffuse alpha source activity compared to the control group. Thus, the ratio of parietal delta and alpha3 source activity served as an EEG marker. The z-score showed a statistically deviant EEG marker (EEG +) in 50% of the HIV individuals before therapy (p Highlights • A statistical z-score tested the effect of antiretroviral therapy on resting state EEG sources in naïve HIV individuals. • Many HIV individuals (50%) had abnormal EEG before the therapy, and > 40% showed its normalization after 5 months of cART. • This procedure might monitor effects of cART on brain function in HIV single individuals. |
| Databáze: | OpenAIRE |
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