Serum interleukin 2 receptor levels in childhood acute lymphoblastic leukemia

Autor:	C H, Pui, S H, Ip, S, Iflah, F G, Behm, B H, Grose, R K, Dodge, W M, Crist, W L, Furman, S B, Murphy, G K, Rivera
Rok vydání:	1988
Předmět:	Adult Male Adolescent Immunology Infant Receptors Interleukin-2 Cell Biology Hematology Prognosis Biochemistry Leukemia Lymphoid Child Preschool Humans Female Receptors Immunologic Child
Zdroj:	Blood. 71:1135-1137
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v71.4.1135.bloodjournal7141135
Popis:	The clinical significance of interleukin 2 receptor (IL2R) concentrations in serum was determined for 344 children with newly diagnosed acute lymphoblastic leukemia (ALL). Serum levels of IL2R in patients (267 to 80,000 U/mL, median 2,007 U/mL) were significantly higher than normal control values (170 to 738 U/mL, median 347 U/mL) (P less than .0001). Measurements in cases of T cell ALL were lower than in the non-T, non-B cases (P = .02). Among the 264 patients with non-T, non-B ALL, but not in those with T cell disease, higher serum IL2R levels (greater than 2,000 U/mL) were associated with a poorer treatment outcome (P = .04). In a multivariate analysis, serum IL2R level contributed independent prognostic information beyond that conveyed by leukocyte count, race, and age (P = .04). One explanation for these results is that soluble IL2R competes with normal lymphocyte- integrated IL2R for the ligand and thus could suppress host antitumor immunity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c83e5c8372915e56b47296deb20a4e0 https://doi.org/10.1182/blood.v71.4.1135.bloodjournal7141135 Zobrazit plný text záznamu