Accelerating ESD-induced gastric ulcer healing using a pH-responsive polyurethane/small intestinal submucosa hydrogel delivered by endoscopic catheter
| Autor: | Yi Zhang, Jin-Kui Pi, Yan Xie, Long-Mei Zhao, Mei Gong, Huiqi Xie, Qi-Juan Yuan, Rui Wang, Xiu-He Lv |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Ulcer healing
medicine.medical_specialty Biocompatibility 02 engineering and technology Gastroenterology Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Internal medicine medicine ESD-induced ulcer small intestinal submucosa Polyurethane pH-sensitive 021001 nanoscience & nanotechnology digestive system diseases Small intestinal submucosa Catheter chemistry polyurethane 030211 gastroenterology & hepatology AcademicSubjects/SCI01410 Epithelium regeneration Swelling medicine.symptom AcademicSubjects/MED00010 bio-adhesion 0210 nano-technology Research Article |
| Zdroj: | Regenerative Biomaterials |
| ISSN: | 2056-3426 2056-3418 |
| DOI: | 10.1093/rb/rbaa056 |
| Popis: | Endoscopic submucosal dissection (ESD) is the standard treatment for early-stage gastric cancer, but the large post-operative ulcers caused by ESD often lead to serious side effects. Post-ESD mucosal repair materials provide a new option for the treatment of post-ESD ulcers. In this study, we developed a polyurethane/small intestinal submucosa (PU/SIS) hydrogel and investigated its efficacy for accelerating ESD-induced ulcer healing in a canine model. PU/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions in vitro. Besides, PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions, thus ensuring the retention time of PU/SIS gels in vivo. In a canine model, PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer sites. PU/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight inflammation. Our findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair. |
| Databáze: | OpenAIRE |
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