Cell therapy with autologous mesenchymal stromal cells in post-traumatic syringomyelia
Autor: | Héctor Guadalajara, Concepción Aguayo, Miguel A. Rico, Miguel Leon, Ernesto Marín, Ignacio Valverde, Damián García-Olmo, David Vazquez, Joaquín Carballido, Gregorio Rodríguez-Boto, Marta Sevilla, Noemi Tapiador, Mercedes Zurita, Cecilia Fernandez, Jesús Vaquero |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Adult Male Cancer Research medicine.medical_specialty Immunology Cell- and Tissue-Based Therapy Mesenchymal Stem Cell Transplantation Cell therapy 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Humans Syrinx (medicine) Spasticity Adverse effect Spinal cord injury Genetics (clinical) Spinal Cord Injuries Paraplegia Transplantation medicine.diagnostic_test business.industry Magnetic resonance imaging Mesenchymal Stem Cells Cell Biology Middle Aged medicine.disease Magnetic Resonance Imaging Syringomyelia Surgery 030104 developmental biology Treatment Outcome Oncology Neuralgia medicine.symptom business 030217 neurology & neurosurgery |
Zdroj: | Cytotherapy. 20(6) |
ISSN: | 1477-2566 |
Popis: | Background aims Recently, clinical studies show that cell therapy with mesenchymal stromal cells (MSCs) improves the sequelae chronically established in paraplegic patients, being necessary to know which of them can obtain better benefit. Methods We present here a phase 2 clinical trial that includes six paraplegic patients with post-traumatic syringomyelia who received 300 million MSCs inside the syrinx and who were followed up for 6 months. Clinical scales, urodynamic, neurophysiological, magnetic resonance (MR) and studies of ano-rectal manometry were performed to assess possible improvements. Results In all the cases, MR at the end of the study showed a clear reduction of the syrinx, and, at this time, signs of improvement in the urodynamic studies were found. Moreover, four patients improved in ano-rectal manometry. Four patients improved in neurophysiological studies, with signs of improvement in evoked potentials in three patients. In the American Spinal Injury Association (ASIA) assessment, only two patients improved in sensitivity, but clinical improvement in neurogenic bowel dysfunction was observed in four patients and three patients described improvement in bladder dysfunction. Spasms reduced in two of the five patients who had them previous to cell therapy, and spasticity was improved in the other two patients. Three patients had neuropathic pain before treatment, and it was reduced or disappeared completely during the study. Only two adverse events ocurred, without relation to the cell therapy. Conclusions Cell therapy can be considered as a new alternative to the treatment of post-traumatic syringomyelia, achieving reduction of syrinx and clinical improvements in individual patients. |
Databáze: | OpenAIRE |
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