The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study
| Autor: | Andrew J. Patterson, Elizabeth A. Warburton, J.M. U-King-Im, Andrew Zalewski, Michael E. Gaunt, Zhi Y. Li, Martin J. Graves, Andy Brown, Jonathan R. Boyle, Jonathan H. Gillard, Peter J. Kirkpatrick, Kevin Varty, Sam R. Miller, Stewart R. Walsh, Paul D. Hayes, Simon P.S. Howarth, Tjun Y. Tang |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Duplex ultrasonography Statin Imaging biomarker medicine.diagnostic_test medicine.drug_class Surrogate endpoint business.industry Atorvastatin Urology Magnetic resonance imaging medicine.disease Stenosis Atheroma medicine cardiovascular diseases Radiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of the American College of Cardiology. 53:2039-2050 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2009.03.018 |
| Popis: | Objectives The aim of this study was to evaluate the effects of low-dose (10 mg) and high-dose (80 mg) atorvastatin on carotid plaque inflammation as determined by ultrasmall superparamagnetic iron oxide (USPIO)-enhanced carotid magnetic resonance imaging (MRI). The hypothesis was that treatment with 80 mg atorvastatin would demonstrate quantifiable changes in USPIO-enhanced MRI-defined inflammation within the first 3 months of therapy. Background Preliminary studies indicate that USPIO-enhanced MRI can identify macrophage infiltration in human carotid atheroma in vivo and hence may be a surrogate marker of plaque inflammation. Methods Forty-seven patients with carotid stenosis >40% on duplex ultrasonography and who demonstrated intraplaque accumulation of USPIO on MRI at baseline were randomly assigned in a balanced, double-blind manner to either 10 or 80 mg atorvastatin daily for 12 weeks. Baseline statin therapy was equivalent to 10 mg of atorvastatin or less. The primary end point was change from baseline in signal intensity (ΔSI) on USPIO-enhanced MRI in carotid plaque at 6 and 12 weeks. Results Twenty patients completed 12 weeks of treatment in each group. A significant reduction from baseline in USPIO-defined inflammation was observed in the 80-mg group at both 6 weeks (ΔSI 0.13; p = 0.0003) and at 12 weeks (ΔSI 0.20; p Conclusions Aggressive lipid-lowering therapy over a 3-month period is associated with significant reduction in USPIO-defined inflammation. USPIO-enhanced MRI methodology may be a useful imaging biomarker for the screening and assessment of therapeutic response to “anti-inflammatory” interventions in patients with atherosclerotic lesions. (Effects of Atorvastatin on Macrophage Activity and Plaque Inflammation Using Magnetic Resonance Imaging [ATHEROMA]; NCT00368589 ) |
| Databáze: | OpenAIRE |
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