Clinical applications of microperimetry in RPGR ‐related retinitis pigmentosa: a review
| Autor: | Buckley, TMW, Jolly, JK, Josan, AS, Wood, LJ, Cehajic-Kapetanovic, J, MacLaren, RE |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures DNA Mutational Analysis Visual Acuity Late disease stage Retina Optical coherence tomography Ophthalmology Retinitis pigmentosa Electroretinography medicine Humans Eye Proteins medicine.diagnostic_test business.industry Disease progression DNA General Medicine medicine.disease eye diseases Pedigree Clinical trial Mutation Visual Field Tests Retinal function sense organs medicine.symptom business Microperimetry Retinitis Pigmentosa Tomography Optical Coherence |
| Zdroj: | Acta Ophthalmologica. 99:819-825 |
| ISSN: | 1755-3768 1755-375X |
| Popis: | Microperimetry, or fundus-tracked perimetry, is a precise static-automated perimetric technique to assess central retinal function. As visual acuity only deteriorates at a late disease stage in RPGR-related retinitis pigmentosa (RP), alternative markers for disease progression are of great utility. Microperimetry assessment has been of critical value as an outcome measure in a recently reported phase I/II gene therapy trial for RPGR-related RP, both in terms of detecting safety and efficacy signals. Here, we performed a review of the literature. We describe the principles of microperimetry before outlining specific parameters that may be useful as outcome measures in clinical trial settings. The current state of structure-function correlations between short-wavelength autofluorescence, optical coherence tomography and adaptive optics in RPGR-related retinitis pigmentosa are also summarized. |
| Databáze: | OpenAIRE |
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